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Decision making by modular polyketide synthases and implications for genetic engineering

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Human microbiota peptides: important roles in human health

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The Rapid Synthesis of Colibactin Warhead Model Compounds Using New Metal‐Free Photocatalytic Cyclopropanation Reactions Facilitates the Investigation of Biological Mechanisms

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Chemistry A European J, 2023, 29
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Manipulating Microbiota in Inflammatory Bowel Disease Treatment: Clinical and Natural Product Interventions Explored

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The synthesis of the novel Escherichia coli toxin—colibactin and its mechanisms of tumorigenesis of colorectal cancer

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Newly Discovered Mechanisms of Antibiotic Self-Resistance with Multiple Enzymes Acting at Different Locations and Stages

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Analysis of the partial sequencing of clbA, clbB and clbQ in Escherichia coli isolates that produce colibactin and multilocus sequence typing

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clbP Gene, a Potential New Member of the β-Lactamase Family

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Synthesis and Biological Evaluation of Colibactin Derivatives

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Chemiluminescent Probes Allow for the Rapid Identification of Colibactin-Producing Bacteria

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Recent Advances of Food Hazard Detection Based on Artificial Nanochannel Sensors

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Small molecules as modulators of phage–bacteria interactions

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Construction and application of a heterogeneous quality control library for the Xpert MTB/RIF assay in tuberculosis diagnosis

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Structure Elucidation of Secondary Metabolites: Current Frontiers and Lingering Pitfalls

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Architecture of a PKS-NRPS hybrid megaenzyme involved in the biosynthesis of the genotoxin colibactin

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Determining the Sequence of Two Colibactin Genes, clbN and clbB, in Some Clinical Isolates of E. coli

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The microbiome-product colibactin hits unique cellular targets mediating host–microbe interaction

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Structural basis of the amidase ClbL central to the biosynthesis of the genotoxin colibactin

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Structure and function of prodrug-activating peptidases

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Prevalence of polyketide synthase (PKS) genotoxin among Escherichia coli isolated from clinical sources

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The microbiome regulates host metabolic health and diseases through microbial enzymes

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Nat Rev Gastroenterol Hepatol, 2026
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Unraveling the Hypervirulent Carbapenem-Resistant Klebsiella pneumoniae Global Epidemiological Landscape and Divergence in Genetic Evolutionary Mechanisms: A Narrative Review

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Advancing the Biosynthetic and Chemical Understanding of the Carcinogenic Risk Factor Colibactin and Its Producers

Yuichiro Hirayama, Michio Sato and Kenji Watanabe

Biochemistry, 2022, 61, 2782
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Screening method toward ClbP-specific inhibitors

Tao Zhou, Takayuki Ando, Akihiro Kudo, Michio Sato, Noriyuki Miyoshi, Michihiro Mutoh, Hideki Ishikawa, Keiji Wakabayashi and Kenji Watanabe

Genes and Environ, 2023, 45
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