1,8-Naphthyridine Derivatives: An Updated Review on Recent Advancements of Their Myriad Biological Activities

Shivani Mithula, Adinarayana Nandikolla, Sankaranarayanan Murugesan and Venkata GCS Kondapalli

Future Med. Chem., 2021, 13, 1591
DOI: 10.4155/fmc-2021-0086

A Four-Component Domino Reaction: An Eco-Compatible and Highly Efficient Construction of 1,8-Naphthyridine Derivatives, Their In Silico Molecular Docking, Drug Likeness, ADME, and Toxicity Studies

Ankita Garg, Aschalew Tadesse, Rajalakshmanan Eswaramoorthy and Simone Carradori

Journal of Chemistry, 2021, 2021, 1
DOI: 10.1155/2021/5589837

Molecular Modeling of Histamine Receptors—Recent Advances in Drug Discovery

Pakhuri Mehta, Przemysław Miszta and Sławomir Filipek

Molecules, 2021, 26, 1778
DOI: 10.3390/molecules26061778

Antioxidant and Antimicrobial Potential of 1,8‐Naphthyridine Based Scaffolds: Design, Synthesis and in Silico Simulation Studies within Topoisomerase II

Nadia A. A. Elkanzi, Hajer Hrichi, Alaa Muqbil Alsirhani and Rania B. Bakr

Chemistry & Biodiversity, 2024, 21
DOI: 10.1002/cbdv.202301746

Design & synthesis of hybrid pharmacophore of β-lactam, 1,8-naphthyridine, and secondary amines; Discover their in vitro antimicrobial, anticancer properties & DFT and ADMET prediction studies

Keyur M. Pandya, Satyanarayana Battula, K. A. Aravinda Kumar, Rajesh J. Patel and Navin B. Patel

Med Chem Res, 2023, 32, 1098
DOI: 10.1007/s00044-023-03058-2

(Mes-Acr-Me)+ClO4– Catalyzed Visible Light-Supported, One-Pot Green Synthesis of 1,8-Naphthyridine-3-Carbonitriles

Sumaiya Tabassum, Santhosh Govindaraju and Pravin Kendrekar

Top Catal, 2025, 68, 1440
DOI: 10.1007/s11244-022-01583-9

Fused chromeno and quinolino[1,8]naphthyridines: Synthesis and biological evaluation as topoisomerase I inhibitors and antiproliferative agents

Endika Martín-Encinas, Gloria Rubiales, Birgitta R. Knudsen, Francisco Palacios and Concepción Alonso

Bioorganic & Medicinal Chemistry, 2021, 40, 116177
DOI: 10.1016/j.bmc.2021.116177

Synthesis, XRD/HSA-interactions, biological activity, optical and nonlinear optical responses studies of new pyran derivative

Ahmed Abderrahim Yahiaoui, Nadir Ghichi, Douniazed Hannachi, Amel Djedouani, Samir Meskaldji, Hocine Merazig and Dominique Harakat

Journal of Molecular Structure, 2022, 1263, 133161
DOI: 10.1016/j.molstruc.2022.133161

Accessing 1,8-Naphthyridone-3-carboxylic Acid Derivatives and Application to the Synthesis of Amfonelic Acid

Kaijuan Wang, Chengcheng Gong, Weiwei Xiao, Ablimit Abdukader and Dong Wang

J. Org. Chem., 2024, 89, 5811
DOI: 10.1021/acs.joc.4c00415

Direct Synthesis, Characterization and Theoretical Studies of N‐(6‐Amino‐1,3‐dimethyl‐2,4‐dioxo‐1,2,3,4‐tetrahydropyrimidin‐5‐yl)benzamide Derivatives

Tushar Das, Amit Ranjan, Lesław Sieroń, Waldemar Maniukiewicz and Subrata Das

ChemistrySelect, 2021, 6, 726
DOI: 10.1002/slct.202004745

4-Bromo-1,8-Naphthalimide derivatives as Antifungal Agents: Synthesis, Characterization, DNA Binding, Molecular docking, Antioxidant and ADMET studies

Nouman, Manish Rana, Saiema Ahmedi, Rizwan Arif, Nikhat Manzoor and Rahisuddin

Polycyclic Aromatic Compounds, 2024, 44, 748
DOI: 10.1080/10406638.2023.2180523

Efficient synthetic strategies for fused pyrimidine and pyridine derivatives: A review

Sharmil N. Anjirwala and Saurabh K. Patel

Journal of Heterocyclic Chem, 2024, 61, 1481
DOI: 10.1002/jhet.4871

1,8-Naphthyridine Derivatives: A Privileged Scaffold for Versatile Biological Activities

Madhwi Ojha, Divya Yadav, Avinash Kumar, Suman Dasgupta and Rakesh Yadav

MRMC, 2021, 21, 586
DOI: 10.2174/1389557520666201009162804

The anti-cancer potential of 2,4,6 tris-methyphenylamino1,3,5-triazine compound against mammary glands cancer: Via down-regulating the hormonal, inflammatory mediators, and oxidative stress

Yumna Mehmood, Fareeha Anwar, Uzma Saleem, Sundas Hira, Bashir Ahmad, Manal Bashir, Muhammad Tayyab Imtiaz, Saima Najm and Tariq Ismail

Life Sciences, 2021, 285, 119994
DOI: 10.1016/j.lfs.2021.119994

Importance of Indazole against Neurological Disorders

Dilipkumar Pal and Pooja Sahu

CTMC, 2022, 22, 1136
DOI: 10.2174/1568026622666220225152443

Schiff Bases From 4‐Aminoantipyrine: Investigation of Their In Silico, Antimicrobial, and Anticancer Effects and Their Use in Glucose Biosensor Design

Aşkın Erbaş, Selinsu Dikim, Fatma Arslan, Onur Can Bodur, Seza Arslan, Fatma Özdemir, Nurşen Sarı and Claudio Pettinari

Bioinorganic Chemistry and Applications, 2025, 2025
DOI: 10.1155/bca/2786064

Synthesis of Isoquinoline‐Containing 5,6‐Dicyano‐2,1,3‐Benzothiadiazoles: Unusual Heterocyclization into Dibenzo‐1,6‐Naphthyridine Framework

Pavel S. Gribanov, Daria V. Vorobyeva, Dmitry A. Loginov, Sergey D. Tokarev, Anna N. Philippova, Alexander F. Smol'yakov, Salekh M. Masoud, Pavel N. Solyev and Sergey N. Osipov

Asian J Org Chem, 2024
DOI: 10.1002/ajoc.202400226

Anti-Cervical Cancer Potential of (E)-3-(Substitutedbenzylidene)-1,8-naphthyridine Derivatives: A Combined Molecular Modelling and Pharmacokinetic Study

P. Trivedi, S. Shukla, P. Sharma, A. Bishnoi, S. Parveen and M. Banerjee

Russ J Gen Chem, 2025, 95, 1359
DOI: 10.1134/S1070363225600523

Raubasine-Induced Groove Binding in Salmon Testes DNA: Exploring the Structural Modulation, Antiglycation, and Antioxidant Properties

Vibeizonuo Rupreo, Deepak Das, Senchumbeni Yanthan and Jhimli Bhattacharyya

J. Phys. Chem. B, 2025, 129, 637
DOI: 10.1021/acs.jpcb.4c07948

Evaluation of pharmacokinetic properties of isobornylphenols in silico

O. I. Ostrikova, O. E. Vaizova, O. I. Aliev, E. V. Buravlev, I. Yu. Chukicheva and A. V. Kutchin

SMJ, 2020, 35, 79
DOI: 10.29001/2073-8552-2020-35-4-79-86