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The design of small-molecule prodrugs and activatable phototherapeutics for cancer therapy

Hai-Hao Han, Han-Min Wang, Paramesh Jangili, Mingle Li, Luling Wu, Yi Zang, Adam C. Sedgwick, Jia Li, Xiao-Peng He, Tony D. James and Jong Seung Kim

Chem. Soc. Rev., 2023, 52, 879
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A new long-wavelength fluorescent probe for tracking peroxynitrite in live cells and inflammatory sites of zebrafish

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Analyst, 2020, 145, 828
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Recent advances in small-molecule fluorescent probes with the function of targeting cancer receptors

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Two-photon imaging of the endoplasmic reticulum thiol flux in the brains of mice with depression phenotypes

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Analyst, 2019, 144, 191
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A fluorescent ESIPT-based benzimidazole platform for the ratiometric two-photon imaging of ONOO−in vitro and ex vivo

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Chem. Sci., 2020, 11, 7329
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Ultra-broadband cyan-to-orange emitting Ba1+xSr1−xGa4O8:Bi3+ phosphors: luminescence control and optical temperature sensing

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Pinkment: a synthetic platform for the development of fluorescent probes for diagnostic and theranostic applications

Maria Weber, Hai-Hao Han, Bo-Han Li, Maria L. Odyniec, Charlotte E. F. Jarman, Yi Zang, Steven D. Bull, Amanda B. Mackenzie, Adam C. Sedgwick, Jia Li, Xiao-Peng He and Tony D. James

Chem. Sci., 2020, 11, 8567
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A novel turn-on fluorescent probe for selective sensing and imaging of glutathione in live cells and organisms

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Analyst, 2019, 144, 3260
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Design and synthesis of a vanadate-based ratiometric fluorescent probe for sequential recognition of Cu2+ ions and biothiols

Hui-Hui Zeng, Zhi-Ying Zhou, Fang Liu, Jie Deng, Shu-Yun Huang, Guo-Ping Li, Pei-Qing Lai, Yue-Ping Xie and Wei Xiao

Analyst, 2019, 144, 7368
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ESIPT-based fluorescence probe for the rapid detection of peroxynitrite ‘AND’ biological thiols

Luling Wu, Hai-Hao Han, Liyuan Liu, Jordan E. Gardiner, Adam C. Sedgwick, Chusen Huang, Steven D. Bull, Xiao-Peng He and Tony D. James

Chem. Commun., 2018, 54, 11336
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Optically superior fluorescent probes for selective imaging of cells, tumors, and reactive chemical species

Abhishek Saini, Jyoti Singh and Sonu Kumar

Org. Biomol. Chem., 2021, 19, 5208
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Insights into the self-aggregating properties of a solvatochromic probe and interaction with β-lactoglobulin

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Coumarin-based fluorescent probe for the rapid detection of peroxynitrite ‘AND’ biological thiols

Luling Wu, Xue Tian, Robin R. Groleau, Jie Wang, Hai-Hao Han, Shaun B. Reeksting, Adam C. Sedgwick, Xiao-Peng He, Steven D. Bull and Tony D. James

RSC Adv., 2020, 10, 13496
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A near-infrared biothiol-specific fluorescent probe for cancer cell recognition

Li Liu, Rui-Jie Lv, Jong-Kai Leung, Qian Zou, Yue Wang, Fei Li, Wang Liang, Shun Feng and Ming-Yu Wu

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NIR two-photon fluorescent probe for biothiol detection and imaging of living cells in vivo

Xiang Xia and Ying Qian

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A specific esterase and pH logically regulate ESIPT: different kinds of granulocyte sorting

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Turn on chemiluminescence-based probes for monitoring tyrosinase activity in conjunction with biological thiols

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Chem. Commun., 2021, 57, 11386
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Multiphoton fluorescence lifetime imaging microscopy (FLIM) and super-resolution fluorescence imaging with a supramolecular biopolymer for the controlled tagging of polysaccharides

Haobo Ge, Fernando Cortezon-Tamarit, Hui-Chen Wang, Adam C. Sedgwick, Rory L. Arrowsmith, Vincenzo Mirabello, Stanley W. Botchway, Tony D. James and Sofia I. Pascu

Nanoscale, 2019, 11, 9498
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A Water-soluble Near-infrared Fluorescent Probe for Cysteine/ Homocysteine and Its Application in Live Cells and Mice

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ANAL. SCI., 2020, 36, 1053
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Monoamine oxidase B activatable red fluorescence probe for bioimaging in cells and zebrafish

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Bioorganic Chemistry, 2024, 145, 107156
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Effect of Substrate Stiffness on Redox State of Single Cardiomyocyte: A Scanning Electrochemical Microscopy Study

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Anal. Chem., 2020, 92, 4771
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Amine‐Templated N,O‐Linked Co(II)‐MOF with hxl Topology for “Turn‐On” Detection of Tumor Biomarker GSH and Industrial Toxicant HCHO: A Dual‐Target Approach

Udayan Mondal, Rajeshwari Pal, Bappaditya Goswami and Priyabrata Banerjee

Analysis & Sensing, 2025
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Nitroxyl donating and visualization with a coumarin-based fluorescence probe

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Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2024, 316, 124317
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Control strategy of displacement processes to sense biothiols via fluorescent changes

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3,5-dinitropyridin-2-yl as a fast thiol-responsive capping moiety in the development of fluorescent probes of biothiols

Junliang Zhou, Shuang Xu, Xiaochun Dong, Weili Zhao and Quangang Zhu

Dyes and Pigments, 2019, 167, 157
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A simple “turn-on” fluorescent probe capable of recognition cysteine with rapid response and high sensing in living cells and zebrafish

Xiaoyan Cao, Hongzhao Lu, Yifan Wei, Lingxia Jin, Qiang Zhang and Bo Liu

Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2022, 275, 121167
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A highly selective ratiometric fluorescent probe for cysteine detection

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Journal of Molecular Structure, 2025, 1335, 142031
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Fluorescein Based Fluorescence Sensors for the Selective Sensing of Various Analytes

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J Fluoresc, 2021, 31, 1251
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Multifunctional Fluorescent Nanoprobe for Sequential Detections of Hg2+ Ions and Biothiols in Live Cells

Lu He, Hui Tao, Seyoung Koo, Guo Chen, Amit Sharma, Yong Chen, In-Taek Lim, Qian-Yong Cao and Jong Seung Kim

ACS Appl. Bio Mater., 2018, 1, 871
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A Simple ESIPT Combines AIE Character 'Turn On' Fluorescent Probe for Hcy/Cys/GSH Detection and Cell Imaging Based on Coumarin Unit

Ge Ding, Xinchao Wang, Derong Luo, Suqi Meng, Linling Zhou, Yinjie Fan, Changxin Ling-hu, Jiangping Meng, Wantong Si and Quanzhou Chen

SSRN Journal, 2022
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A Red-Emission Fluorescent Probe with Large Stokes Shift for Detection of Viscosity in Living Cells and Tumor-Bearing Mice

Beilei Wang, Dezhi Yang, Xiaohong Zhong, Yuhui Liu and Yong Huang

Molecules, 2024, 29, 1993
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A turn-on MOF-based luminescent sensor for highly selective detection of glutathione

Jiayan Zhu, Tifeng Xia, Yuanjing Cui, Yu Yang and Guodong Qian

Journal of Solid State Chemistry, 2019, 270, 317
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Meso-Substituent-Directed Aggregation Behavior and Water Solubility: Direct Functionalization of Methine Chain in Thiazole Orange and Biological Applications in Aqueous Buffer

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A lysosome targeting probe based on fluorescent protein chromophore for selectively detecting GSH and Cys in living cells

Baoxing Shen, Wenyu Zhu, Xu Zhi and Ying Qian

Talanta, 2020, 208, 120461
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A fluorescent probe capable of naked eye recognition for the selective detection of biothiols

Liuqi Qiao, Yongxing Yang, Yaping Li, Xin Lv and Junsheng Hao

Journal of Photochemistry and Photobiology A: Chemistry, 2022, 425, 113654
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A novel pH probe based on tetrahydropyridine synthesis and its application in bioimaging

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Journal of Molecular Liquids, 2025, 424, 127088
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A Cleavable Fluorescent Polymer Visual Sensor for Evaluating Oxidative Stress through the Detection of Reductive Thiols

Zejian He, Wanting Huang, Zhen He, Guangguo Wang, Yifan Zhang, Jia Chen and Mi Zhou

ACS Appl. Polym. Mater., 2025, 7, 10259
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A novel simple red emitter characterized with AIE plus intramolecular charge transfer effects and its application for thiol-containing amino acids detection

Youhong Huang, Ju Mei and Xiang Ma

Dyes and Pigments, 2019, 165, 499
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Fluorescent probes and functional materials for biomedical applications

Xi-Le Hu, Hui-Qi Gan, Fan-De Meng, Hai-Hao Han, De-Tai Shi, Shu Zhang, Lei Zou, Xiao-Peng He and Tony D. James

Front. Chem. Sci. Eng., 2022, 16, 1425
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An ESIPT Probe for the Ratiometric Imaging of Peroxynitrite Facilitated by Binding to Aβ-Aggregates

Adam C. Sedgwick, Wei-Tao Dou, Jin-Biao Jiao, Luling Wu, George T. Williams, A. Toby A. Jenkins, Steven D. Bull, Jonathan L. Sessler, Xiao-Peng He and Tony D. James

J. Am. Chem. Soc., 2018, 140, 14267
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ICT-modulated NIR water-soluble fluorescent probe with large Stokes shift for selective detection of cysteine in living cells and zebrafish

Xufeng Hou, Zhensheng Li, Yunqiang Li, Qihang Zhou, Chunhui Liu, Dang Fan, Jinjin Wang, Ruijie Xu and Zhihong Xu

Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2021, 246, 119030
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Reaction-Based Fluorescent Probes for the Detection and Imaging of Reactive Oxygen, Nitrogen, and Sulfur Species

Luling Wu, Adam C. Sedgwick, Xiaolong Sun, Steven D. Bull, Xiao-Peng He and Tony D. James

Acc. Chem. Res., 2019, 52, 2582
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De novo design of dual-detection fluorescent sensors for bisulfite and copper (II) ion based on cascade activation

Tian Tan, Wenyu Xi, Chenxu Duan, Ying Han, Peikun Xiao, Hongqi Yin, Hong Huang, Xulang Chen, Yanjun Hu and Xiaohuan Huang

Analytica Chimica Acta, 2025, 1346, 343789
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Evaluation of a novel pyridinium cation-linked styryl-based boronate probe for the detection of selected inflammation-related oxidants

Przemysław Siarkiewicz, Bogusława Luzak, Radosław Michalski, Angelika Artelska, Marcin Szala, Tomasz Przygodzki, Adam Sikora, Jacek Zielonka, Aleksandra Grzelakowska and Radosław Podsiadły

Free Radical Biology and Medicine, 2024, 212, 255
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A simple ESIPT combines AIE character “turn on” fluorescent probe for Hcy/Cys/GSH detection and cell imaging based on coumarin unit

Ge Ding, Xinchao Wang, Derong Luo, Suqi Meng, Linling Zhou, Yinjie Fan, Changxin Ling-hu, Jiangping Meng, Wantong Si, Quanzhou Chen and Ruiming Bi

Dyes and Pigments, 2023, 208, 110762
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Iodization-enhanced fluorescence and circularly polarized luminescence for dual-readout probe design

Jun Gong, Ruishan Huang, Chunfei Wang, Zujin Zhao, Ben Zhong Tang and Xuanjun Zhang

Sensors and Actuators B: Chemical, 2021, 347, 130610
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Construction of GSH activated near-infrared fluorescent and photoacoustic dual-modal probe for in vivo tumor imaging

Jingcan Qin, Hao Tian, Fei Kong, Yuanyuan Guo, Wenxian Du, Chuan Zhang, Hongmei Gu and Yuehua Li

Sensors and Actuators B: Chemical, 2022, 371, 132522
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Special issue on “Fluorescent probes”

Adam C. Sedgwick and Tony D. James

Front. Chem. Sci. Eng., 2020, 14, 1
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Nile-Red-Based Fluorescence Probe for Selective Detection of Biothiols, Computational Study, and Application in Cell Imaging

Xiang Rong, Zhong-Yong Xu, Jin-Wu Yan, Zhi-Zhong Meng, Bin Zhu and Lei Zhang

Molecules, 2020, 25, 4718
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Real-Time Fluorescence Imaging of the Abscisic Acid Receptor Allows Nondestructive Visualization of Plant Stress

Jing-Fang Yang, Wei-Jie Chen, Li-Ming Zhou, Kamalani Achala H. Hewage, Yi-Xuan Fu, Mo-Xian Chen, Bo He, Rong-Jie Pei, Ke Song, Jian-Hua Zhang, Jun Yin, Ge-Fei Hao and Guang-Fu Yang

ACS Appl. Mater. Interfaces, 2022, 14, 28489
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A visible and near-infrared, dual emission fluorescent probe based on thiol reactivity for selectively tracking mitochondrial glutathione in vitro

Yue Xu, Ruixi Li, Xiaojing Zhou, Weiqing Li, Umeorah Ernest, Hao Wan, Li Li, Haiyan Chen and Zhenwei Yuan

Talanta, 2019, 205, 120125
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Tunable Aggregation-Induced Emission Nanoparticles by Varying Isolation Groups in Perylene Diimide Derivatives and Application in Three-Photon Fluorescence Bioimaging

Luyi Zong, Hequn Zhang, Yaqin Li, Yanbin Gong, Dongyu Li, Jiaqiang Wang, Zhe Wang, Yujun Xie, Mengmeng Han, Qian Peng, Xuefeng Li, Jinfeng Dong, Jun Qian, Qianqian Li and Zhen Li

ACS Nano, 2018, 12, 9532
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A homocysteine-selective fluorescent probe for cell imaging based on substitution-rearrangement process

Linlin Yang, Pengli Gu, Beining Li, Junwan Li, Aoxiang Fu, Xianyu Gong, Yanmei Huang, Lixia Xie, Liguo Ji, Nana Ma, Lili Li and Guangjie He

Dyes and Pigments, 2022, 207, 110802
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Design of fluorescent probes with optimized responsiveness and selectivity to GSH

Ji-An Chen, Zhen-Yu Zhang, Jie Gao, Jia-Hui Tan and Xian-Feng Gu

Tetrahedron Letters, 2019, 60, 1226
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Fluorescent nucleobase analogs constructed by aldol‐type condensation: Design, properties, and synthetic optimization for fluorogenic labeling of 5‐formyluracil

Hayeon Choi, Hokyung Kim and Ki Tae Kim

Bulletin Korean Chem Soc, 2022, 43, 868
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Long Wavelength TCF-Based Fluorescent Probe for the Detection of Alkaline Phosphatase in Live Cells

Lauren Gwynne, Adam C. Sedgwick, Jordan E. Gardiner, George T. Williams, Gyoungmi Kim, John P. Lowe, Jean-Yves Maillard, A. Toby A. Jenkins, Steven D. Bull, Jonathan L. Sessler, Juyoung Yoon and Tony D. James

Front. Chem., 2019, 7
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A Copper (II) Ensemble-Based Fluorescence Chemosensor and Its Application in the ‘Naked–Eye’ Detection of Biothiols in Human Urine

Yue Wang, Huan Feng, Haibo Li, Xinyi Yang, Hongmin Jia, Wenjun Kang, Qingtao Meng, Zhiqiang Zhang and Run Zhang

Sensors, 2020, 20, 1331
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Water-Soluble Dual-Channel Fluorescent Probe for Sensitive Detection of Biothiols In Vitro and In Vivo

Zhenbo Gao, Hang Yang, Lingzi Ran, Dan Zhang, Yong Ren, Feiyi Wang, Jun Ren and Erfei Wang

ACS Appl. Bio Mater., 2023, 6, 5828
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Development of a semiacenaphthenofluorescein-based optical and fluorescent sensor for imaging cysteine in cells

Xufeng Hou, Zhensheng Li, Yang Wang, Bolun Li, Chunhui Liu, Qiangqiang Zhan, Gaobing Liu, Diandian Wei and Zhihong Xu

Journal of Photochemistry and Photobiology A: Chemistry, 2020, 386, 112090
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An indole–based near–infrared fluorescent “Turn–On” probe for H2O2: Selective detection and ultrasensitive imaging of zebrafish gallbladder

Neha Jain, Prasad M. Sonawane, Arkaprava Roychaudhury, Su Jeong Park, Jongkeol An, Cheol-Hee Kim, Satish Balasaheb Nimse and David G. Churchill

Talanta, 2024, 269, 125459
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On the chemical reactivity of tricyanofuran(TCF)-based near-infrared fluorescent redox probes – Effects of glutathione on the probe response and product fluorescence

Przemysław Siarkiewicz, Radosław Michalski, Adam Sikora, Renata Smulik-Izydorczyk, Marcin Szala, Aleksandra Grzelakowska, Julia Modrzejewska, Asha Bailey, Jacek E. Nycz, Balaraman Kalyanaraman, Jan Grzegorz Malecki, Jacek Zielonka and Radosław Podsiadły

Dyes and Pigments, 2021, 192, 109405
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An ESIPT coupled AIE fluorescent probe for biothiols detection and imaging based on a chalcone fluorophore

Fangfang Dai, Min Zhao, Fangzhou Yang, Tingting Wang and Chao Wang

Dyes and Pigments, 2020, 183, 108627
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Fluorescent Sensing of Glutathione and Related Bio-Applications

Xiaohuan Sun, Fei Guo, Qianyun Ye, Jinfeng Zhou, Jie Han and Rong Guo

Biosensors, 2022, 13, 16
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A Phenothiazine-HPQ Based Fluorescent Probe with a Large Stokes Shift for Sensing Biothiols in Living Systems

Yan Zheng, Peng Hou, Yu Li, Jingwen Sun, Hongxia Cui, Haiyan Zhang and Song Chen

Molecules, 2021, 26, 2337
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The Evaluation of Ester Functionalised TCF‐Based Fluorescent Probes for the Detection of Bacterial Species

Lauren Gwynne, George T. Williams, Kai‐Cheng Yan, Jordan E. Gardiner, Kira L. F. Hilton, Bethany L. Patenall, Jennifer R. Hiscock, Jean‐Yves Maillard, Xiao‐Peng He, Tony D. James, Adam C. Sedgwick and A. Toby A. Jenkins

Israel Journal of Chemistry, 2021, 61, 234
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Rational design of a far-red fluorescent probe for endogenous biothiol imbalance induced by hydrogen peroxide in living cells and mice

Zhengliang Lu, Xin Sun, Mengzhao Wang, Hongmei Wang, Chunhua Fan and Weiying Lin

Bioorganic Chemistry, 2020, 103, 104173
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A novel sensitive fluorescent probe with double channels for highly effective recognition of biothiols

Qiang Fei, Keyi Shen, Hongxiu Ke, Erfei Wang, Guorun Fan, Feiyi Wang and Jun Ren

Bioorganic & Medicinal Chemistry Letters, 2024, 97, 129563
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Protein Encapsulation: A Nanocarrier Approach to the Fluorescence Imaging of an Enzyme-Based Biomarker

Zhiyuan Jia, Hai-Hao Han, Adam C. Sedgwick, George T. Williams, Lauren Gwynne, James T. Brewster, Steven D. Bull, A. Toby A. Jenkins, Xiao-Peng He, Holger Schönherr, Jonathan L. Sessler and Tony D. James

Front. Chem., 2020, 8
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An aggregation induced emission chalcone fluorescent probe with large Stokes shift for biothiols detection

Rong Tang, Chao Wang, Xuan Zhou, Mengxiang Feng, Zefei Li, Yihan Wang and Guang Chen

Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2023, 300, 122870
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Red and Near-Infrared Fluorescent Probe for Distinguishing Cysteine and Homocysteine through Single-Wavelength Excitation with Distinctly Dual Emissions

Taiyu Guo, Xinyue Chen, Wangbo Qu, Bin Yang, Ruowei Tian, Zhirong Geng and Zhilin Wang

Anal. Chem., 2022, 94, 5006
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