Issue 13, 2022

Decarboxylative cyclization of o-chlorobenzoic acids with C,C-palladacycles formed by an aminopalladation/dealkylation strategy to access dibenzo[a,c]carbazoles

Abstract

Herein a novel palladium-catalyzed tandem decarboxylative biscyclization of o-alkynylanilines with o-chlorobenzoic acids has been reported, which provides an efficient approach for the assembly of dibenzo[a,c]carbazoles. This protocol employs an intramolecular aminopalladation/dealkylation strategy to form C,C-palladacycles, which allow the construction of one C–N bond and two C–C bonds by reacting with o-chlorobenzoic acids. The method features a broad substrate scope and excellent functional group compatibility.

Graphical abstract: Decarboxylative cyclization of o-chlorobenzoic acids with C,C-palladacycles formed by an aminopalladation/dealkylation strategy to access dibenzo[a,c]carbazoles

Supplementary files

Article information

Article type
Research Article
Submitted
27 mar 2022
Accepted
06 maj 2022
First published
06 maj 2022

Org. Chem. Front., 2022,9, 3414-3419

Decarboxylative cyclization of o-chlorobenzoic acids with C,C-palladacycles formed by an aminopalladation/dealkylation strategy to access dibenzo[a,c]carbazoles

X. Chen, S. Lei, Y. Chen, W. Deng, G. Deng, Y. Liang and Y. Yang, Org. Chem. Front., 2022, 9, 3414 DOI: 10.1039/D2QO00490A

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