Issue 51, 2023

A practical synthesis of 1,3-disubstituted cubane derivatives

Abstract

A robust multigram-scale synthesis of 1,3-disubstituted cubanes (previously only available on milligram-scale) is reported. The approach exploits a readily available enone intermediate previously used for the synthesis of 1,4-disubstituted cubanes, by introducing a novel Wharton transposition to access useful quantities of 1,3-disubstituted cubanes for diverse applications.

Graphical abstract: A practical synthesis of 1,3-disubstituted cubane derivatives

Supplementary files

Article information

Article type
Communication
Submitted
03 maj 2023
Accepted
30 maj 2023
First published
31 maj 2023
This article is Open Access
Creative Commons BY license

Chem. Commun., 2023,59, 7971-7973

A practical synthesis of 1,3-disubstituted cubane derivatives

N. Kazi, M. C. Aublette, S. L. Allinson and S. C. Coote, Chem. Commun., 2023, 59, 7971 DOI: 10.1039/D3CC02164E

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