Regio- and diastereoselective construction of 1′,2′-(dihydrospiro[indoline-3,3′-pyrrol]-2′-yl)acrylates through phosphine-catalyzed [4 + 1] annulation of Morita–Baylis–Hillman carbonates with oxindole-derived α,β-unsaturated imines

Abstract

Phosphine-catalyzed [4 + 1] annulation of Morita–Baylis–Hillman (MBH) carbonates with oxindole-derived α,β-unsaturated imines has been developed, giving the corresponding 1′,2′-(dihydrospiro[indoline-3,3′-pyrrol]-2′-yl)acrylates in moderate to good yields and diastereoselectivities under mild conditions.