Pyrazolopyridines have gained increasing attention in kinase-targeting anti-cancer drug discovery. This review analyzes the success stories wherein this bicycle was employed to address various challenges.
A comprehensive outlook of PROTAC breakthroughs in targeting anti-inflammatory and auto-immune diseases as promising therapeutic approaches for various unresolved disorders.
We propose a computational framework to explore pocket-aware inhibitors targeting the J pocket of BTK kinase by integrating generative deep learning, molecular docking, and molecular dynamics simulations.
Peptide-based passivation strategies were developed to prevent the unintended conjugation of his-tagged enzymes to quantum dot (QD) biosensors, enabling the application of QD biosensors in complex assays such as CRISPR-based diagnostics.
New pyrimidine-based carbocylic nucleoside derivatives with C-4 substitution for inhibiting α-glucosidase as a means of alleviating the effects of diabetes mellitus (DM) and microbial infections.