A novel enamino ester was synthesized and studied via DFT. NMR, MEP, Fukui, and docking show its stability, reactivity, and antibacterial potential. ADME-Tox predicts good pharmacokinetics and low toxicity, supporting drug development.
Vinyl cyclopropane scaffolds were synthesized via a proline-catalysed multicomponent reaction involving vinyl sulfoxonium ylides, aldehydes, and indane 1,3-dione.
We report an electrochemical sulfinylation protocol that drives a skeletal rearrangement of Baylis–Hillman adducts, enabling the late-stage synthesis of methyl (Z)-3-(aryl/heteroaryl)-2-[(aryl/alkyl)sulfinyl]methyl acrylates.
Lewis acid promoted spiro annulation for the one-pot synthesis of novel pyrrole–quinazoline hybrid molecules as described.
A convenient synthesis of enantiopure mixed donor phosphine–phosphite ligands has been developed incorporating P-stereogenic phosphanorbornane and axially chiral bisnaphthols into one ligand structure.