This feature article highlights recent advances in leveraging the synthetic potential of α-diazo compounds for the development of novel and versatile chemical transformations.
The recent advances in trifluoroethylation reactions were summarized based on the bond formation: C(sp)–CH2CF3, C(sp2)–CH2CF3, C(sp3)–CH2CF3, and X (X = N, O, S, Se)–CH2CF3.
Recent advances in the preparation of trifluoromethyl-containing heterocyclics via trifluoromethyl building block strategies over the period from 2019 to the present are systematically summarized and discussed.
An efficient iron-catalyzed sulfur alkylation of sulfenamides with diazo compounds for the synthesis of functionalized sulfilimines is developed under air conditions.
A highly efficient and chemoselective approach has been developed for the O- and S- trifluoroethylation of oxindoles, isoindolines, and thio-oxindoles utilizing Brønsted acid catalysis under greener protocol.