A radical initiated cascadecyclization reaction has been realized to access various pyrrolo[1,2-a]indol-3-ones. Mechanistic studies, scale-up synthesis, and further transformations of this high value method were also demonstrated.
A simple radical nitro/azide cyclization of 1-acryloyl-2-cyanoindoles produced diverse NO2/N3-featuring pyrrolo[1,2-a] indolediones.
This review presents a comprehensive overview of recent synthetic strategies for constructing indolo[2,1-a]isoquinoline derivatives from N-acryloyl indole precursors.
By harnessing the reactivity of alkynes and alkenes under photochemical conditions, novel pathways have been unlocked to construct N-heterocyclic compounds, allowing for more efficient and sustainable synthesis.
This review highlights the synthesis of pharmaceutically important indolo/benzimidazo-isoquinoline derivatives via photo-, and electro-mediated functionalization/cyclization reactions of N-methacryloyl 2-aryl indoles/benzimidazoles.