A reductive cross-coupling of diaryl disulfides with aryl bromides via an unusual C–S bond cleavage with the aid of a nickel catalyst, Mg, and LiCl in THF at room temperature was developed, providing a variety of biaryls in reasonable yields.
An efficient cobalt-catalyzed cross-electrophile coupling (XEC) reaction of aryl halides with linear secondary alkyl halides to construct C(sp3)–C(aryl) motif was reported. The key to the reaction is the use of a phosphino-oxazoline (PHOX) ligand.
An efficient Fe-catalyzed cross-electrophile vinyl silylation protocol is reported for the first time. A set of 1,4-diene silanes are conveniently synthesized from simple vinyl chlorosilanes and alkenyl bromides under mild reductive conditions.
The direct functionalization of alcohols via C–O bond cleavage is a synthetically valuable but challenging transformation. The cobaltaelectrocatalysis cross-coupling allows the direct coupling of benzylic alcohols with arylchlorides to diarylmethane.
We report a dynamic kinetic cross-electrophile coupling reaction of benzylic alcohols with alkenyl triflates. The reaction enables replacement of the alcohol group with an alkenyl functionality, yielding versatile benzyl-substituted cyclic alkenes.