We report a Pd-catalyzed reductive Heck cyclization of alkene-tethered carbamoyl chlorides to synthesize of CH3- and CH2D-functionalized oxindoles. The practical value is highlighted by one-pot protocols and formal synthesis of bioactive molecules.
We report a Pd-catalyzed Heck/polyfluoroarylation reaction for the synthesis of polyfluoroarylated oxindoles. This method was expanded to a three-component one-pot procedure, and an initial asymmetric version was also demonstrated.
We report a palladium-catalyzed Heck-carbonylation of alkene-tethered carbamoyl chlorides with aryl formates, which afforded diversiform esterified oxindoles/γ-lactams bearing an all-carbon quaternary stereocenter.
2-Oxindole based natural products and bioactive molecules.
This review aims to collect advancements in enantioselective palladium-catalyzed cyclization reactions over the past eleven years, and it is organized into thirteen sections depending on the different types of transformations involved.