Recent progress in the assembly of chiral α-tertiary amines in the last decade via transition-metal catalysis is summarized.
This work summarizes recent progress in nickel-catalyzed propargylic substitution reactions, categorizing them based on the diverse types of nucleophiles involved, with a specific focus on exploring asymmetric transformations.
DFT calculations were conduct to elucidate the catalytic mechanism of the target asymmetric propargylic substitution (APS) reaction. Moreover, we rationally designed a more efficient axial chiral phosphine ligand for the APS reaction.
Heteroatom-substituted axially chiral allenes represent an important subclass of chiral allenes. We summarizes the contributions on heteroatom-substituted axially chiral allenes and their catalytic asymmetric synthesis and synthetic applications.
The key progress in the field of N-heterocyclic carbene (NHC) organocatalysis during the period of 2015 to 2024 is systematically summarized and discussed in this review.