A practical protocol has been established to access 2-aminoquinazolin-4(3H)-one derivatives through the electrochemical desulfurative cyclization of 2-aminobenzamides and isothiocyanates.
The synthesis of N-heterocycles has been considered an emerging topic of chemical research due to its widespread usage in medicinal chemistry, materials science, and natural product synthesis.
DMSO-assisted approach for the synthesis of N-alkylated quinazolinones from readily available 2-aminobenzamide and aryl methyl ketones has been developed. DMSO played a dual role, acting as a solvent as well as a dual carbon synthon, making this process an environmentally benign approach.
The activation and utilization of challenging aliphatic alcohols like methanol and ethanol is a very appealing approach to synthesize valuable organic molecules.