The work offers an elegant paradigm for designing a ratiometric NIR-II probe by modulating the fluorescence behaviour of anionic cyanine scaffolds, which was successfully used for in vivo fluorescence angiography and precise tumours localization.
γ-Glutamyl transpeptidase (GGT) regulates glutathione (GSH), essential for cell functions and linked to cancer.
This review mainly describes the design principles and mechanisms of activatable probes for the fluorescence imaging of tumors.
Bimodal chiral fluorescence probes (ACx-GGTB) were developed to perform fluorescent-plane polarization dual-mode imaging, and realize simultaneous and differential monitoring of transferase activities at different sites during migration.
This review summarizes not only the fluorescent probes of rhodamine derivatives, but also the recent advances in rhodamine-based PSs in the treatment of various disease models.