Sorbicillinoids are a growing class of fungal natural products combining complex molecular architectures with pharmaceutically relevant bioactivities. This review covers their structural diversity, biosynthesis, and synthetic studies.
This study presents a rhodium(III)-catalyzed asymmetric allylic cyclization of cyclohexadienone-tethered allenes, affording cis-hydrobenzofurans with good yields and enantioselectivities. Compound 3ha shows promising anticancer properties.
The asymmetric catalytic synthesis of 1,2-diamines has received considerable interest, due to their presence in biologically active compounds and their applications for the development of synthetic building blocks, chiral ligands and organocatalysts.
A perfectly chemo- and stereoselective desymmetrization of 2,5-cyclohexadienones has been described, where the domino process is initiated by the organocatalyzed enantioselective conjugate addition to the appended 4-nitro-5-styrylisoxazoles.
A squaramide-catalyzed regio-/enantioselective sulfa-1,6-addition initiated highly enantio- and diastereoselective desymmetrization of 2,5-cyclohexadienone-tethered 3-cyano-4-styrylcoumarins has been disclosed.