COMBINED INTRAVITREAL AFLIBERCEPT AND ANTI-INFLAMMATORY ORAL SUPPLEMENTATION IN THE TREATMENT OF DIABETIC MACULAR EDEMA

Paola Marolo, Giovanni Li Volti, Anna Nicolosi, Teresio Avitabile, Antonio Longo, Matteo Fallico, Andrea Russo, Enrico Borrelli, Guglielmo Parisi, Mario Damiano Toro, Ugo de Sanctis, Lorenzo Motta and Michele Reibaldi

Retina, 2025, 45, 1134
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Beneficial Effects Induced by a Proprietary Blend of a New Bromelain-Based Polyenzymatic Complex Plus N-Acetylcysteine in Urinary Tract Infections: Results from In Vitro and Ex Vivo Studies

Lucia Recinella, Morena Pinti, Maria Loreta Libero, Silvia Di Lodovico, Serena Veschi, Anna Piro, Daniele Generali, Alessandra Acquaviva, Nilofar Nilofar, Giustino Orlando, Annalisa Chiavaroli, Claudio Ferrante, Luigi Menghini, Simonetta Cristina Di Simone, Luigi Brunetti, Mara Di Giulio and Sheila Leone

Antibiotics, 2024, 13, 985
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Nutritional Composition and Therapeutic Potential of Pineapple Peel – A Comprehensive Review

Mahrukh Mehraj, Susmita Das, Fathima Feroz, Ab Waheed Wani, S.Q Dar, Sanjeev Kumar, Atif Khurshid Wani and Arshad Farid

Chemistry & Biodiversity, 2024, 21
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Purification and functional characterization of two basic proteases of South American Bromelia antiacantha fruit

Diego Vallés, Carolina Villadóniga and Ana M.B. Cantera

Biochimie, 2026, 244, 117
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Poly(ε-Caprolactone)/Poly(Ethylene Glycol)Dithiol Electrospun Nanofibers As a Carrier for the Potent Phytomedicine Bromelain

Ozan Yeşiltepe, Nefise Yılmaz, Özge Kozguş Güldü, Ecem Saygılı, Emin İlker Medine and Dilek Odacı

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Mucoadhesive-to-Mucopenetrating Nanoparticles for Mucosal Drug Delivery: A Mini Review

Bin Zheng, Dingyi Liu, Xiaowen Qin, Dahong Zhang and Pu Zhang

IJN, 2025, Volume 20, 2241
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Mucin O‐Glycosylation and Mucolytic Therapies in Pseudomyxoma Peritonei: Literature Review

Qi‐Di Zhao, David L. Morris, Zheng‐Long Sun and Yan Li

Medicinal Research Reviews, 2026
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In vivo effect of bromelain from Ananas comosus on Staphylococcus aureus skin infection in an animal model

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IJMLST, 2025, 7, 80
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AI-Driven Rapid Screening and Characterization of Dipeptidyl Peptidase-IV (DPP-IV) Inhibitory Peptides from Goat Blood Proteins: An Integrative In Silico and Experimental Strategy

Jingjie Tan, Sirong Huang, Dongjing Wu, Zhongquan Zhao, Yongju Zhao, Yu Fu and Wei Wu

Foods, 2026, 15, 398
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Effects of Bromelain and Papain in Tooth Whitening and Caries Removal: A Literature Review

Stanca Cuc, Amalia Moldovan, Marioara Moldovan, Codruta Sarosi, Smaranda Buduru, Cecilia Bacali, Doina Prodan, Viorica Lazar and Sorin Claudiu Man

Dentistry Journal, 2025, 13, 132
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Dual natural enzyme-tuned biomineralized nanoflowers for boosting cascade catalytic antibacterial therapy and relieving inflammation

Hanyu Zhang, Mingdi Zheng, Meng Hao, Xiao Dong, Gemeng Liang, Jinshuo Zou, Yongxin Li and Peitao Xie

Adv Compos Hybrid Mater, 2025, 8
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Synergic Role of Dietary Bioactive Compounds in Breast Cancer Chemoprevention and Combination Therapies

Marisabel Mecca, Marzia Sichetti, Martina Giuseffi, Eugenia Giglio, Claudia Sabato, Francesca Sanseverino and Graziella Marino

Nutrients, 2024, 16, 1883
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Bromelain‐Rich Pineapple Extract for the Treatment of Pediatric Patients With Orchiepididymitis: A Randomized Clinical Pilot Study

Alessandro Colletti, Luciano Sangiorgio, Alma Martelli, Marzia Pellizzato and Giancarlo Cravotto

Molecular Nutrition Food Res, 2025, 69
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Extraction and characterization of biomaterials from pork bones: a potential alternative of pineapple by-product extract for commercial proteases

Van-Ba Hoa, Won-Seo Park, Jun-Sang Ham and In-Seon Bae

Food Sci Anim Resour, 2026, 46
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Exploring the Therapeutic Potential of Bromelain: Applications, Benefits, and Mechanisms

Urna Kansakar, Valentina Trimarco, Maria V. Manzi, Edoardo Cervi, Pasquale Mone and Gaetano Santulli

Nutrients, 2024, 16, 2060
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Bromelain in Obesity Therapy: A Review of Anti-Inflammatory and Metabolic Mechanisms

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IJMS, 2025, 26, 8347
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Pharmacological potential of fruit‑residue bioactives in skin health: Molecular mechanisms, cosmetic applications, and valorization

Ghada Alhamdani, Maged Alkanad, Nischith Sirawase Shankar, Maged Mohammed Abdo Mohsen and Annegowda Hardur Venkatappa

Pharmacological Research - Natural Products, 2026, 11, 100604
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Antimicrobial Properties of Citrus limon L. Peel, Pineapple Peel, and Fruit Extracts Against Some Oral Pathogens

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Int J Enteric Pathog, 2023, 11, 122
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Antibacterial and antifungal activities of protease loaded modified thermoplastic starch blown PBAT films for active packaging

Phatthranit Klinmalai, Jenjira Leelapatarapun, Phanwipa Wongphan and Nathdanai Harnkarnsujarit

Food Packaging and Shelf Life, 2025, 50, 101541
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Emerging Phytochemical Formulations for Management of Rheumatoid Arthritis: A Review

Prachi Pimple, Jenny Shah and Prabha Singh

CDD, 2025, 22, 15
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Effects of bromelain, melatonin, and thymoquinone on neutrophil extracellular trap formation and macrophage polarization in experimental periodontitis

Şükran Acipinar, Mustafa Ozkaraca, Ufuk Okkay and Ali Sefa Mendil

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Advanced functional plasmonic-carbon dot hybrid platforms: nanoarchitecture, sensing mechanisms, chemical sensors, and future perspectives

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Proteolytic Enzyme Activities of Bromelain, Ficin, and Papain from Fruit By-Products and Potential Applications in Sustainable and Functional Cosmetics for Skincare

Maria Venetikidou, Eleni Lykartsi, Theodora Adamantidi, Vasileios Prokopiou, Anna Ofrydopoulou, Sophia Letsiou and Alexandros Tsoupras

Applied Sciences, 2025, 15, 2637
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Asymmetric bioactive phosphorus dendrimers deliver bromelain for enhanced anti-inflammation and chondroprotection therapy of osteoarthritis

Huxiao Sun, Jin Li, Mengsi Zhan, Yu Zou, Caiyun Zhang, Serge Mignani, Regis Laurent, Jean-Pierre Majoral, Xiangyang Shi and Mingwu Shen

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Precision hydrolysis: tailored yeast processing enzymes for yeast-based products

Jieying Deng, Zhendong Li, Xueqin Lv, Jian Chen and Long Liu

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Bromelain Improves Hypothalamic Control of Energy Homeostasis in High-Fat Diet-Induced Obese Rats

Raviye Ozen Koca, Mustafa Berk Basaran, Hatice Solak and Zulfikare Isik Solak Gormus

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Bromelain mitigates monosodium glutamate-induced neurobehavioral impairment in mice by modulating AChE-MAO-GAD and oxido-inflammatory pathways: Experimental and computational insights

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Antioxidant, Hypotensive, and Antidiabetic Breakthroughs: Bromelain Hydrolysis Unlocks Quinoa’s Peptide Potential - In Silico and In Vitro Approach

Maria Lilibeth Manzanilla-Valdez, Sarita Montaño, Cristina Martinez-Villaluenga, Fernanda Zúñiga, Christine Boesch and Alan Javier Hernandez-Alvarez

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Reduction of Post-Surgical Facial Edema Following Bromelain and Coumarin Intake in Traumatology: A Prospective Study with 100 Patients

Giuseppe Consorti, Gabriele Monarchi, Mariagrazia Paglianiti, Enrico Betti and Paolo Balercia

JCM, 2024, 13, 922
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Green synthesis of selenium-zinc oxide using Ananas comosus extract co-doped graphene oxide for biological activities

Tran Dang Khoa, Doan Thi Yen Oanh, Chau Hong Nhung, Ly Gia Man, Mai Thi Thao Nguyen, Pham Duc Nghi, Le Thanh Hoang Duc, Nguyen Hung Vu, Dang Thanh Cong Minh, Nguyen Thanh Hoai Nam, Tran Nguyen Cam Nhung and Nguyen Huu Hieu

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Anticancer Potential of Pineapple and its Bioactive Compound Bromelain

Davinder Kumar, Suchitra, Jyoti Mundlia, Shiv Kumar Yadav, Deepika Yadav, Navidha Aggarwal, Hitesh Chopra, Virender Kumar and Mohammad Amjad Kamal

CPD, 2025, 31, 461
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Evaluating the role of bromelain in diabetes management: a systematic review of research evidence and mechanisms of action

Jaafaru Sani Mohammed, Abdulrahman T Ahmed, Mandeep Singh, Malathi Hanumanthayya, Syeda Wajida Kazmi, Mamata Chahar, Hussein Riyadh Abdul Kareem Al-Hetty, Hanen Mahmod Hulail, Mohammed Qasim Alasheqi and Ahmed Hussein Zwamel

Journal of Pharmacy and Pharmacology, 2025, 77, 884
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Plant and Arthropod IgE-Binding Papain-like Cysteine Proteases: Multiple Contributions to Allergenicity

Ivana Giangrieco, Maria Antonietta Ciardiello, Maurizio Tamburrini, Lisa Tuppo, Adriano Mari and Claudia Alessandri

Foods, 2024, 13, 790
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Review perspective on advanced nutrachemicals and anterior cruciate ligament rehabilitation

Dai Haojie, Sohini Mukherjee and Tanima Bhattacharya

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Tracking heterogenous protein aggregation at nanoscale through fluorescence correlation spectroscopy

Bisal Halder, Shreya Ghosh, Tanmoy Khan, Subhendu Pal, Nilimesh Das and Pratik Sen

Photochem & Photobiology, 2024, 100, 989
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Preventive Role of Cocoa-Enriched Extract Against Neuroinflammation in Mice

Ivan Carrera, Lola Corzo, Olaia Martínez-Iglesias, Vinogran Naidoo and Ramón Cacabelos

Neurology International, 2025, 17, 47
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The role of Bromelain and Liposomal Vitamin C in the treatment of chronic venous disease

Giacomo Buso, Paolo Santini, Francesca Ghirardini, Francesca Cannavacciuolo, Adriana Visonà, Beniamino Zalunardo, Roberto Pola and Romeo Martini

Vasa, 2025, 54, 164
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Hepato(Geno)toxicity Assessment of Different Bromelain Food Supplements in HepG2 Cell Line Model by the Comet Assay

Tugce Yesil, Muzeyyen Tugce Karakas Demir , Merve Hidiroglu and Seher Karsli

Pharmedicine J., 2025, 2, 8
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