Novel pancreatic lipase inhibitory peptides derived from lotus seed protein: isolation, identification, and the interaction mechanism

Haoran Chen, Zhenling Lang, Jingwen Chen, Tingting Gao, Baodong Zheng and Shaoxiao Zeng

Food Funct., 2025, 16, 3180
DOI: 10.1039/D5FO01008J

EVALUATION OF ETHANOLIC EXTRACT OF TILIACORA ACUMINATA LEAVES FOR PANCREATIC LIPASE INHIBITION AND LIPID MODULATION: IN SILICO AND IN VITRO STUDIES

SHRIPRASANTH BHASKARAN, ANUSHA D, KARTHIKA K and KAVITHA RAMASAMY

Asian J Pharm Clin Res, 2025, 175
DOI: 10.22159/ajpcr.2025v18i4.53932

Synthesis and Characterization of Short α and β-Mixed Peptides with Excellent Anti-Lipase Activities

Naeem Ahmed, Sabahat Asif, Muhammad Arfan, Qaiser Mahmood, Amjad Islam, Mansour K. Gatasheh and Muhammad Zia

Molecules, 2024, 29, 765
DOI: 10.3390/molecules29040765

Isolation and identification of novel hemp seed protein-derived pancreatic lipase inhibitory peptides

Zhenghai Zhang, Jingyi Ge, Lianhui Wei, Jie Shi, Yanru Ji, Xiangyu Xing, Yu Shi and Yan Dong

Food Bioscience, 2025, 63, 105834
DOI: 10.1016/j.fbio.2025.105834

Preparation and characterization of a sea cucumber collagen-derived peptide and the inhibition of pancreatic lipase

Zhe Xu, Jiale Chang, Zijin Qin, Hanxiong Liu, Xu Yan, Shuang Guan, Xiufang Dong, Jianping Wu and Tingting Li

Food Bioscience, 2025, 65, 106013
DOI: 10.1016/j.fbio.2025.106013

Food bioactive peptides: functionality beyond bitterness

Silvia Tagliamonte, Veronica Oliviero and Paola Vitaglione

Nutrition Reviews, 2025, 83, 369
DOI: 10.1093/nutrit/nuae008

Influence of Enzymatic Hydrolysis and Molecular Weight Fractionation on the Antioxidant and Lipase / α-Amylase Inhibitory Activities In Vitro of Watermelon Seed Protein Hydrolysates

Armin Mirzapour-Kouhdasht, Marco Garcia-Vaquero, Jong-Bang Eun and Jesus Simal-Gandara

Molecules, 2022, 27, 7897
DOI: 10.3390/molecules27227897

Surface display of pancreatic lipase inhibitor peptides by engineered Saccharomyces boulardii: Potential as an anti-obesity probiotic

Mahsa Nayebhashemi, Somayeh Enayati, Mozhgan Zahmatkesh, Hamid Madanchi, Samaneh Saberi, Ehsan Mostafavi, Esmat Mirbzadeh Ardakani, Mohammad Azizi and Vahid Khalaj

Journal of Functional Foods, 2023, 102, 105458
DOI: 10.1016/j.jff.2023.105458

Role of pancreatic lipase inhibition in obesity treatment: mechanisms and challenges towards current insights and future directions

Vetriselvan Subramaniyan and Yusoff Umul Hanim

Int J Obes, 2025, 49, 492
DOI: 10.1038/s41366-025-01729-1

Lemon basil seed-derived peptide: Hydrolysis, purification, and its role as a pancreatic lipase inhibitor that reduces adipogenesis by downregulating SREBP-1c and PPAR-γ in 3T3-L1 adipocytes

Kittisak Kuptawach, Sajee Noitung, Anumart Buakeaw, Songchan Puthong, Ruengwit Sawangkeaw, Papassara Sangtanoo, Piroonporn Srimongkol, Onrapak Reamtong, Kiattawee Choowongkomon, Aphichart Karnchanatat and Fahrul Nurkolis

PLoS ONE, 2024, 19, e0301966
DOI: 10.1371/journal.pone.0301966

Okra seeds proteins: Amino acid profile, free radical scavenging activities and inhibition of diabetes and hypertensive converting enzymes indices

Oluwole Steve Ijarotimi, Abimbola Olayemi Akinola-Ige and Timilehin David Oluwajuyitan

Measurement: Food, 2023, 11, 100101
DOI: 10.1016/j.meafoo.2023.100101

Insights into rapid screening and molecular mechanism of novel Rosa roxburghii seeds pancreatic lipase/cholesterol esterase inhibitory peptides: a combined in silico and in vitro perspective

Hao Yin, Jiangxiong Zhu, Yu Zhong, Danfeng Wang, Yun Deng, Yongli Jiang, Linnan Yang and Lutao Gao

Food Science and Human Wellness, 2025, 14, 9250163
DOI: 10.26599/FSHW.2024.9250163

Fabrication and Characterization of a Lipase Inhibition Protein Hydrolysate Derived from Baby Clam (Corbiculidae sp.) Meat

Tam Dinh Le Vo, Bao Chi Vo, Khoi Tri Nguyen and Hieu Hoang Nguyen

Waste Biomass Valor, 2025
DOI: 10.1007/s12649-025-03141-2

Hypolipidemic Activity of Protein Hydrolysate from Sacha inchi Meal

Xi Chen, Kai Wang and Xuewu Zhang

Waste Biomass Valor, 2023, 14, 2707
DOI: 10.1007/s12649-023-02035-5

Kinetic and thermodynamic-based studies on the interaction mechanism of novel R. roxburghii seed peptides against pancreatic lipase and cholesterol esterase

Hao Yin, Jiangxiong Zhu, Yu Zhong, Danfeng Wang and Yun Deng

Food Chemistry, 2024, 447, 139006
DOI: 10.1016/j.foodchem.2024.139006

Effect of extracted rice protein hydrolysate on high-fat diet induced obesity in mice

Yu Matsumoto, Yu Iwasaki, Megumi Hosokawa, Tsukasa Suzuki, Jun Inoue, Yasutaka Shigemura, Katsumi Takano and Yuji Yamamoto

Journal of The Japanese Society for Food Science and Technology, 2023, 70, 177
DOI: 10.3136/nskkk.NSKKK-D-22-00090

Enhanced Antioxidant and Digestive Enzyme Inhibitory Activities of Pacific White Shrimp Shell Protein Hydrolysates via Conjugation with Polyphenol: Characterization and Application in Surimi Gel

Akanksha R. Gautam, Soottawat Benjakul, Deepak Kadam, Brijesh Tiwari and Avtar Singh

Foods, 2024, 13, 4022
DOI: 10.3390/foods13244022

Pancreatic lipase inhibitory effects of peptides derived from sesame proteins: In silico and in vitro analyses

Xinyi Wang, Xin Ai, Zehui Zhu, Mingxin Zhang, Fei Pan, Zichen Yang, Ou Wang, Liang Zhao and Lei Zhao

International Journal of Biological Macromolecules, 2022, 222, 1531
DOI: 10.1016/j.ijbiomac.2022.09.259

Peptides Evaluated In Silico, In Vitro, and In Vivo as Therapeutic Tools for Obesity: A Systematic Review

Ana Júlia Felipe Camelo Aguiar, Wendjilla Fortunato de Medeiros, Juliana Kelly da Silva-Maia, Ingrid Wilza Leal Bezerra, Grasiela Piuvezam and Ana Heloneida de Araújo Morais

IJMS, 2024, 25, 9646
DOI: 10.3390/ijms25179646

Boswellia sp. oleogum resins: high-performance thin-layer chromatography‒effect-directed pancreatic lipase inhibition profiles and molecular docking studies

Burak Temiz, Hale Gamze Agalar, Mehlika Dilek Altıntop and Stefan Gafner

JPC-J Planar Chromat, 2024, 37, 567
DOI: 10.1007/s00764-025-00331-5

Biaryl carboxamide‐based peptidomimetics analogs as potential pancreatic lipase inhibitors for treating obesity

Vikash Pandey, Patil A. Adhikrao, Gudle M. Motiram, Nisha Yadav, Utkarsh Jagtap, Gautam Kumar and Atish Paul

Archiv der Pharmazie, 2024, 357
DOI: 10.1002/ardp.202300503

Research progress in lipid metabolic regulation of bioactive peptides

Wenshu Ma, Na Li, Luan Lin, Jiahui Wen, Chao Zhao and Fang Wang

Food Prod Process and Nutr, 2023, 5
DOI: 10.1186/s43014-022-00123-y

Optimizing and Characterization of Soybean Oil Seed Cake Protein Hydrolysis: In Vitro Analysis

Haifa Hamza, Deepika Kaushik, Harmandeep Kaur, Rajdeep Kaur, Matteo Bordiga, Yassine Jaouhari, Charalampos Proestos, Mukhtar Ahmed, Mohammad Rizwan Khan, Fatih Oz and Mukul Kumar

Food Science & Nutrition, 2025, 13
DOI: 10.1002/fsn3.70270

Composition, Microbiota, Mechanisms, and Anti-Obesity Properties of Rice Bran

Bhagavathi Sundaram Sivamaruthi, Karthikeyan Alagarsamy, Subramanian Thangaleela, Muruganantham Bharathi, Periyanaina Kesika and Chaiyavat Chaiyasut

Foods, 2023, 12, 1300
DOI: 10.3390/foods12061300

A comprehensive review on the pancreatic lipase inhibitory peptides: A future anti-obesity strategy

Tan Yong Chia, Chee-Yuen Gan, Muhammad Hakimin Shafie, Pei Gee Yap, Ainolsyakira Mohd Rodhi, Ashfaq Ahmad, Vikneswaran Murugaiyah, Mohammed H Abdulla and Edward James Johns

ELECTRON J GEN MED, 2023, 20, em470
DOI: 10.29333/ejgm/12943

Recent advances in the valorization of seed wastes as source of bioactive peptides with multifunctional properties

Raffaella Colombo, Vanessa Pellicorio, Marta Barberis, Ilaria Frosi and Adele Papetti

Trends in Food Science & Technology, 2024, 144, 104322
DOI: 10.1016/j.tifs.2023.104322

Investigating the cellular antioxidant and anti-inflammatory effects of the novel peptides in lingzhi mushrooms

Thanyaporn Aursuwanna, Sajee Noitang, Papassara Sangtanoo, Piroonporn Srimongkol, Tanatorn Saisavoey, Songchan Puthong, Onrapak Reamtong and Aphichart Karnchanatat

Heliyon, 2022, 8, e11067
DOI: 10.1016/j.heliyon.2022.e11067

Natural Lipase Inhibitors in Recent Years: A Review

Metin Bülbül and Selin Çokdinleyen

ChemistrySelect, 2024, 9
DOI: 10.1002/slct.202401091

The optimal transglutaminase concentrations to improve the delivery efficiency and cholesterol-lowering ability of novel resveratrol-loaded soybean protein– or soybean peptide–based nanogels

Mengxue Fang, Chaoting Wen, Fei Ma, Li Yu, Du Wang, Liangxiao Zhang and Peiwu Li

Food Hydrocolloids, 2025, 163, 111078
DOI: 10.1016/j.foodhyd.2025.111078