Accessing local electron-beam induced temperature changes during in situ liquid-phase transmission electron microscopy

Birk Fritsch, Andreas Hutzler, Mingjian Wu, Saba Khadivianazar, Lilian Vogl, Michael P. M. Jank, Martin März and Erdmann Spiecker

Nanoscale Adv., 2021, 3, 2466
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MeasureIce: accessible on-the-fly measurement of ice thickness in cryo-electron microscopy

Hamish G. Brown and Eric Hanssen

Commun Biol, 2022, 5
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Mixing and Flow Control of Liquids in Nanochannel Liquid Phase Electron Microscopy

Tayyaba Malik, Emil Christian Stillhoff, Mads Søndergaard Larsen, Murat Nulati Yesibolati and Kristian Mølhave

Microsc Microanal, 2021, 27, 99
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Elastic and inelastic mean free paths for scattering of fast electrons in thin-film oxides

Adham Basha, George Levi, Tamir Amrani, Yang Li, Guy Ankonina, Pini Shekhter, Lior Kornblum, Ilan Goldfarb and Amit Kohn

Ultramicroscopy, 2022, 240, 113570
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High-resolution and analytical electron microscopy in a liquid flow cell via gas purging

Yevheniy Pivak, Junbeom Park, Shibabrata Basak, Rüdiger-Albert Eichel, Anne Beker, Alejandro Rozene, Héctor Hugo Pérez Garza and Hongyu Sun

Microscopy, 2023, 72, 520
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Exploring Biomineralization Processes Using In Situ Liquid Transmission Electron Microscopy: A Review

Liza‐Anastasia DiCecco, Tengteng Tang, Eli D. Sone and Kathryn Grandfield

Small, 2025, 21
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Visualizing Electrochemical CO2 Reduction Reaction: Recent Progress of In Situ Liquid Cell Transmission Electron Microscopy

Zeyu Guo, Paul Paciok, Robert Zandonella, Huiwen Zhu, Pengyi Tang, Pengfei Cao, Ziyun Xi, Joachim Mayer, Jordi Arbiol, Tao Wu and Mengxia Xu

Adv Funct Materials, 2025
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Tailoring the Acidity of Liquid Media with Ionizing Radiation: Rethinking the Acid–Base Correlation beyond pH

Birk Fritsch, Andreas Körner, Thaïs Couasnon, Roberts Blukis, Mehran Taherkhani, Liane G. Benning, Michael P. M. Jank, Erdmann Spiecker and Andreas Hutzler

J. Phys. Chem. Lett., 2023, 14, 4644
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Liquid-cell annular dark-field scanning transmission electron microscopy imaging of single crystal samples on a low-index zone-axis incidence condition

Masaki Takeguchi, Jonathan Lueke, Matthew Reynolds, Baibing Zhao and Ayako Hashimoto

Micron, 2025, 198, 103888
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Liquid Phase Electron Microscopy Provides Opportunities in Polymer Synthesis and Manufacturing

Wyeth Gibson and Joseph P. Patterson

Macromolecules, 2021, 54, 4986
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Optimizing Contrast in Automated 4D STEM Cryotomography

Shahar Seifer, Peter Kirchweger, Karlina Maria Edel and Michael Elbaum

Microscopy and Microanalysis, 2024, 30, 476
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Trapping Nanoparticles in Nanofluidic Traps Using a Monolithic Liquid Phase-TEM Chip

Niccolò Bottauscio, Mervan Ramadan, Oliver Lin, Zhiheng Lyu, Chansong Kim, Sofie Tidemand-Lichtenberg, Joakim Lajer, Qian Chen, Emil C S Jensen and Kristian S Mølhave

Microscopy and Microanalysis, 2025, 31
DOI: 10.1093/mam/ozaf048.931

Quantifying Aqueous Radiolytic Products in Liquid Phase Electron Microscopy

Rolf Erling Robberstad Møller-Nilsen, Silvia Canepa, Eric Jensen, Hongyu Sun, Ivan A. Moreno-Hernandez, Murat Nulati Yesibolati, A. Paul Alivisatos and Kristian S. Mølhave

J. Phys. Chem. C, 2023, 127, 15512
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In-Situ 4D-STEM Mapping of Crystalline Orientation and 3D Topology of Gold Nanorods in Liquid Phase

Parivash Moradifar, Amy Siobhan McKeown-Green, Stephanie Ribet, Alan Dai, Niccolo Bottauscio, Colin Ophus and Jennifer Dionne

Microscopy and Microanalysis, 2025, 31
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Benchmarking the ideal sample thickness in cryo-EM

Michael W. Martynowycz, Max T. B. Clabbers, Johan Unge, Johan Hattne and Tamir Gonen

Proc. Natl. Acad. Sci. U.S.A., 2021, 118
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Reducing the effects of radiation damage in cryo-EM using liquid helium temperatures

Joshua L. Dickerson, Katerina Naydenova, Mathew J. Peet, Hugh Wilson, Biplob Nandy, Greg McMullan, Robert Morrison and Christopher J. Russo

Proc. Natl. Acad. Sci. U.S.A., 2025, 122
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Observing ion diffusion and reciprocating hopping motion in water

Sangui Liu, Xinbao Han, Colin Ophus, Shiyuan Zhou, You-Hong Jiang, Yue Sun, Tiqing Zhao, Fei Yang, Meng Gu, Yuan-Zhi Tan, Shi-Gang Sun, Haimei Zheng and Hong-Gang Liao

Sci. Adv., 2023, 9
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Nanoscale architecture of synaptic vesicles and scaffolding complexes revealed by cryo-electron tomography

Richard G. Held, Jiahao Liang and Axel T. Brunger

Proc. Natl. Acad. Sci. U.S.A., 2024, 121
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Radiolysis‐Driven Evolution of Gold Nanostructures – Model Verification by Scale Bridging In Situ Liquid‐Phase Transmission Electron Microscopy and X‐Ray Diffraction

Birk Fritsch, Tobias S. Zech, Mark P. Bruns, Andreas Körner, Saba Khadivianazar, Mingjian Wu, Neda Zargar Talebi, Sannakaisa Virtanen, Tobias Unruh, Michael P. M. Jank, Erdmann Spiecker and Andreas Hutzler

Advanced Science, 2022, 9
DOI: 10.1002/advs.202202803

Liquid Phase Electron Microscopy of Bacterial Ultrastructure

Brian J. Caffrey, Adrián Pedrazo‐Tardajos, Emanuela Liberti, Benjamin Gaunt, Judy S. Kim and Angus I. Kirkland

Small, 2024, 20
DOI: 10.1002/smll.202402871

Correlating cryo-super resolution radial fluctuations and dual-axis cryo-scanning transmission electron tomography to bridge the light-electron resolution gap

Peter Kirchweger, Debakshi Mullick, Prabhu Prasad Swain, Sharon G. Wolf and Michael Elbaum

Journal of Structural Biology, 2023, 215, 107982
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Unhindered Brownian Motion of Individual Nanoparticles in Liquid-Phase Scanning Transmission Electron Microscopy

Murat Nulati Yesibolati, Kim I. Mortensen, Hongyu Sun, Anders Brostrøm, Sofie Tidemand-Lichtenberg and Kristian Mølhave

Nano Lett., 2020, 20, 7108
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Considerations of Liquid-Phase Transmission Electron Microscopy Applied to Heterogeneous Electrocatalysis

Tzu-Hsien Shen, Robin Girod, Jan Vavra and Vasiliki Tileli

J. Electrochem. Soc., 2023, 170, 056502
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Nanofluidic chips for cryo-EM structure determination from picoliter sample volumes

Stefan T Huber, Edin Sarajlic, Roeland Huijink, Felix Weis, Wiel H Evers and Arjen J Jakobi

eLife, 2022, 11
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Bringing Structure to Cell Biology with Cryo-Electron Tomography

Lindsey N. Young and Elizabeth Villa

Annu. Rev. Biophys., 2023, 52, 573
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Mapping and Controlling Liquid Layer Thickness in Liquid‐Phase (Scanning) Transmission Electron Microscopy

Hanglong Wu, Hao Su, Rick R. M. Joosten, Arthur D. A. Keizer, Laura S. van Hazendonk, Maarten J. M. Wirix, Joseph P. Patterson, Jozua Laven, Gijsbertus de With and Heiner Friedrich

Small Methods, 2021, 5
DOI: 10.1002/smtd.202001287

Precision of Radiation Chemistry Networks: Playing Jenga with Kinetic Models for Liquid-Phase Electron Microscopy

Birk Fritsch, Paolo Malgaretti, Jens Harting, Karl J. J. Mayrhofer and Andreas Hutzler

Precision Chemistry, 2023, 1, 592
DOI: 10.1021/prechem.3c00078

Advanced Materials for Energy-Water Systems: The Central Role of Water/Solid Interfaces in Adsorption, Reactivity, and Transport

Edward Barry, Raelyn Burns, Wei Chen, Guilhem X. De Hoe, Joan Manuel Montes De Oca, Juan J. de Pablo, James Dombrowski, Jeffrey W. Elam, Alanna M. Felts, Giulia Galli, John Hack, Qiming He, Xiang He, Eli Hoenig, Aysenur Iscen, Benjamin Kash, Harold H. Kung, Nicholas H. C. Lewis, Chong Liu, Xinyou Ma, Anil Mane, Alex B. F. Martinson, Karen L. Mulfort, Julia Murphy, Kristian Mølhave, Paul Nealey, Yijun Qiao, Vepa Rozyyev, George C. Schatz, Steven J. Sibener, Dmitri Talapin, David M. Tiede, Matthew V. Tirrell, Andrei Tokmakoff, Gregory A. Voth, Zhongyang Wang, Zifan Ye, Murat Yesibolati, Nestor J. Zaluzec and Seth B. Darling

Chem. Rev., 2021, 121, 9450
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Plasmon spectroscopy for the determination of Ti3C2T x MXene few layer stacks architecture

T Bilyk, H-W Hsiao, R Yuan, M Benchakar, A Habrioux, S Célérier, J-M Zuo, J Pacaud and V Mauchamp

2D Mater., 2022, 9, 035017
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MeasureIce: Accessible Ice Thickness Measurement for Single Particle Cryogenic Transmission Electron Microscopy

Hamish Brown and Eric Hanssen

Microscopy and Microanalysis, 2022, 28, 1232
DOI: 10.1017/S1431927622005128

Quantification of reagent mixing in liquid flow cells for Liquid Phase-TEM

Stefan Merkens, Giuseppe De Salvo, Joscha Kruse, Evgenii Modin, Christopher Tollan, Marek Grzelczak and Andrey Chuvilin

Ultramicroscopy, 2023, 245, 113654
DOI: 10.1016/j.ultramic.2022.113654

A cryo-TSEM with temperature cycling capability allows deep sublimation of ice to uncover fine structures in thick cells

Jiro Usukura, Akihiro Narita, Tomoharu Matsumoto, Eiji Usukura, Takeshi Sunaoshi, Syunya Watanabe, Yusuke Tamba, Yasuhira Nagakubo, Takashi Mizuo, Junzo Azuma, Masako Osumi, Kazutaka Nimura, Ryuichiro Tamochi and Yoichi Ose

Sci Rep, 2021, 11
DOI: 10.1038/s41598-021-00979-z

Interface-Sensitive Soft X-ray Absorption Spectroscopy by Electron/Ion-Yield Methods and Its Application to Solid–Liquid Interfaces for SrTiO3 and CoOOH

Zi Wang, Ryo Toyoshima, Kota Enomoto, Kazuhiko Mase and Hiroshi Kondoh

J. Phys. Chem. C, 2025, 129, 2570
DOI: 10.1021/acs.jpcc.4c06654

Observing the Dynamics of an Electrochemically Driven Active Material with Liquid Electron Microscopy

Wyeth Gibson, Justin T. Mulvey, Swetamber Das, Serxho Selmani, Jovany G. Merham, Alexander M. Rakowski, Eric Schwartz, Allon I. Hochbaum, Zhibin Guan, Jason R. Green and Joseph P. Patterson

ACS Nano, 2024, 18, 11898
DOI: 10.1021/acsnano.4c01524

Diffusively Controlled Growth of Nanobubbles under Contact Line Pinning: Implication of Nanoscale Flow and Heat Controls by Nanobubbles

Heejun Choi, Guanglei Chen and Calvin H. Li

ACS Appl. Nano Mater., 2022, 5, 8991
DOI: 10.1021/acsanm.2c01223

Plasma FIB milling for the determination of structures in situ

Casper Berger, Maud Dumoux, Thomas Glen, Neville B.-y. Yee, John M. Mitchels, Zuzana Patáková, Michele C. Darrow, James H. Naismith and Michael Grange

Nat Commun, 2023, 14
DOI: 10.1038/s41467-023-36372-9

The Influence of Ionizing Radiation on Quantification for In Situ and Operando Liquid‐Phase Electron Microscopy

Birk Fritsch, Serin Lee, Andreas Körner, Nicholas M. Schneider, Frances M. Ross and Andreas Hutzler

Advanced Materials, 2025, 37
DOI: 10.1002/adma.202415728

Thickness- and quality-controlled fabrication of fluorescence-targeted frozen-hydrated lamellae

Daan B. Boltje, Radim Skoupý, Clémence Taisne, Wiel H. Evers, Arjen J. Jakobi and Jacob P. Hoogenboom

Cell Reports Methods, 2025, 5, 101004
DOI: 10.1016/j.crmeth.2025.101004

Quantitative atomic cross section analysis by 4D-STEM and EELS

Shahar Seifer, Lothar Houben and Michael Elbaum

Ultramicroscopy, 2024, 259, 113936
DOI: 10.1016/j.ultramic.2024.113936

Real-space imaging of nanoparticle transport and interaction dynamics by graphene liquid cell TEM

Sungsu Kang, Ji-Hyun Kim, Minyoung Lee, Ji Woong Yu, Joodeok Kim, Dohun Kang, Hayeon Baek, Yuna Bae, Byung Hyo Kim, Seulki Kang, Sangdeok Shim, So-Jung Park, Won Bo Lee, Taeghwan Hyeon, Jaeyoung Sung and Jungwon Park

Sci. Adv., 2021, 7
DOI: 10.1126/sciadv.abi5419

Imaging biological macromolecules in thick specimens: The role of inelastic scattering in cryoEM

Joshua L. Dickerson, Peng-Han Lu, Dilyan Hristov, Rafal E. Dunin-Borkowski and Christopher J. Russo

Ultramicroscopy, 2022, 237, 113510
DOI: 10.1016/j.ultramic.2022.113510