Trends of antimalarial marine natural products: progresses, challenges and opportunities

Yang Hai, Zi-Mu Cai, Peng-Jie Li, Mei-Yan Wei, Chang-Yun Wang, Yu-Cheng Gu and Chang-Lun Shao

Nat. Prod. Rep., 2022, 39, 969
DOI: 10.1039/D1NP00075F

An integrated theoretical study on natural alkaloids as SARS-CoV-2 main protease inhibitors: a step toward discovery of potential drug candidates with anti-COVID-19 activity

Shagufta Parveen, Laiba Shahbaz, Nusrat Shafiq, Maryam Rashid, Mohamed Mohany and Mingkun Zhu

RSC Adv., 2025, 15, 2045
DOI: 10.1039/D4RA06536K

Mechanistic insight into the role of mevalonate kinase by a natural fatty acid-mediated killing of Leishmania donovani

Surendra Rajit Prasad, Prakash Kumar, Saptarshi Mandal, Anu Mohan, Radhika Chaurasia, Ashish Shrivastava, Pallaprolu Nikhil, Dande Aishwarya, P. Ramalingam, Rahul Gajbhiye, Shriya Singh, Arunava Dasgupta, Mukesh Chourasia, V. Ravichandiran, Prolay Das and Debabrata Mandal

Sci Rep, 2022, 12
DOI: 10.1038/s41598-022-20509-9

Screening of Beta-glucosidase inhibitors and their Chemical Profiles from Marine sediment Bacteria

Burcu Omuzbuken, Asli Kacar, Sibel Avunduk and Idil Erden Pazi

Thalassas, 2022, 38, 1057
DOI: 10.1007/s41208-022-00451-3

In Vitro and In Vivo Leishmanicidal Activity of Beauvericin

Virlânio A. de Oliveira Filho, Juliana R. Gubiani, Vitória D. Borgonovi, Felipe Hilário, Marcelo R. de Amorim, Karen Minori, Vitor K. S. Bertolini, Antonio G. Ferreira, Andressa R. Biz, Marcos A. Soares, Helder L. Teles, Fernanda R. Gadelha, Roberto G. S. Berlinck and Danilo C. Miguel

J. Nat. Prod., 2024, 87, 2829
DOI: 10.1021/acs.jnatprod.4c01098

Study on Bioactive Secondary Metabolites from the Mangrove-Derived Fungus Penicillium verruculosum TGM14

Bin Wang, Xu-Hua Nong, Wei-Nv Zeng, Shan-Shan Li, Gao-Yu Li, Jing Liu, Guo-Lei Huang and Cai-Juan Zheng

Chem Nat Compd, 2022, 58, 812
DOI: 10.1007/s10600-022-03804-9

Investigation of Proximate Analysis and Phytochemical Screening of Dry Orange Waste (Citrus sinensis) Extract: From Agrowaste to Sustainable Development

K.D. Akinlabu, T. F. Owoeye, M. E. Emetere, H. O. Jonathan, D. I. Owoeye and P. O. Akinlabu

IOP Conf. Ser.: Earth Environ. Sci., 2024, 1342, 012016
DOI: 10.1088/1755-1315/1342/1/012016

Laurequinone, a Lead Compound against Leishmania

Sara García-Davis, Atteneri López-Arencibia, Carlos J. Bethencourt-Estrella, Desirée San Nicolás-Hernández, Ezequiel Viveros-Valdez, Ana R. Díaz-Marrero, José J. Fernández, Jacob Lorenzo-Morales and José E. Piñero

Marine Drugs, 2023, 21, 333
DOI: 10.3390/md21060333

Metal complexes as potential anti-Trypanosoma agents: a bibliographic review

Silvania Siqueira Nogueira, Paulo Sérgio de Araújo Sousa, Mariana Fochesato, Jefferson Almeida Rocha and Leiz Maria Costa Veras

Cad. Pedagógico, 2025, 22, e14464
DOI: 10.54033/cadpedv22n4-271

A Marine Natural Product, Harzianopyridone, as an Anti-ZIKV Agent by Targeting RNA-Dependent RNA Polymerase

Kexin Zhang, Jingyao Liang, Bingzhi Zhang, Lishan Huang, Jianchen Yu, Xuhan Xiao, Zhenjian He, Huaming Tao and Jie Yuan

Molecules, 2024, 29, 978
DOI: 10.3390/molecules29050978

Neopetrotaurines A–C, Isoquinoline Alkaloids with an Unprecedented Taurine Bridge from the Sponge Neopetrosia sp

Dongdong Wang, Wei Jiang, Mehal Churiwal, Katrina Jia, Sarath P. D. Senadeera, Heidi R. Bokesch, Girma M. Woldemichael, Yong Kim, Robert G. Hawley, Jun S. Wei, Javed Khan, Barry R. O’Keefe, John A. Beutler and Kirk R. Gustafson

J. Nat. Prod., 2024, 87, 332
DOI: 10.1021/acs.jnatprod.3c01041

Development of New Leishmanicidal Compounds via Bioconjugation of Antimicrobial Peptides and Antileishmanial Guanidines

Natalia C. S. Costa, Luana Ribeiro dos Anjos, João Victor Marcelino de Souza, Maria Carolina Oliveira de Arruda Brasil, Vitor Partite Moreira, Marcia A. S. Graminha, Gert Lubec, Eduardo Rene P. Gonzalez and Eduardo Maffud Cilli

ACS Omega, 2023, 8, 34008
DOI: 10.1021/acsomega.3c04878

Anthelmintic Potential of Conjugated Long-Chain Fatty Acids Isolated from the Bioluminescent Mushroom Neonothopanus gardneri

Maria D. A. Oliveira, Teresinha de Jesus A. dos S. Andrade, Joaquim S. C. Junior, Nerilson Marques Lima, Hugo G. Machado, Jioji N. Tabudravu, Francisco das Chagas L. Pinto, Lucas Fukui-Silva, Monique C. Amaro, Josué de Moraes, Dulce Helena S. Silva, Antônia Maria das Graças L. Citó and Chistiane Mendes Feitosa

J. Nat. Prod., 2025, 88, 255
DOI: 10.1021/acs.jnatprod.4c00546

New developments in the treatment of cutaneous leishmaniasis

Rasit Dinc

Asian Pacific Journal of Tropical Medicine, 2022, 15, 196
DOI: 10.4103/1995-7645.345944

Salt-Tolerant Plants as Sources of Antiparasitic Agents for Human Use: A Comprehensive Review

Maria Rodrigues, Catarina Pereira, Marta Oliveira, Gökhan Zengin and Luísa Custódio

Marine Drugs, 2023, 21, 66
DOI: 10.3390/md21020066

Modifications and hybrids of 1,2,3,4-tetrahydropyridinium salts and their antiprotozoal potencies

Werner Seebacher, Noor-ul-Amin Mohsin, Johanna Dolensky, Patrick Hochegger, Marcel Kaiser, Pascal Mäser, Robert Saf, Daniela Schuster, Veronika Temml and Robert Weis

Monatsh Chem, 2021, 152, 1347
DOI: 10.1007/s00706-021-02847-y

Ageladine A, a Bromopyrrole Alkaloid from the Marine Sponge Agelas nakamurai

George E. Magoulas

Compounds, 2023, 3, 107
DOI: 10.3390/compounds3010010

Antiprotozoal Activity and Cytotoxicity Screening of Lippia adoensis (Hochst.) Extracts: Growth Inhibition of Plasmodium, Leishmania, and Trypanosoma Parasites

Eugenie Aimée Madiesse Kemgne, Mariscal Brice Tchatat Tali, Darline Dize, Cyrille Armel Njanpa Ngansop, Boniface Pone Kamdem and Fabrice Fekam Boyom

JOMA, 2025, 2, 6
DOI: 10.3390/joma2010006

Neolignans isolated from Saururus cernuus L. (Saururaceae) exhibit efficacy against Schistosoma mansoni

Juliana R. Brito, Polrat Wilairatana, Daniel B. Roquini, Beatriz C. Parra, Marina M. Gonçalves, Dalete Christine S. Souza, Edgard A. Ferreira, Maria C. Salvadori, Fernanda S. Teixeira, João Henrique G. Lago and Josué de Moraes

Sci Rep, 2022, 12
DOI: 10.1038/s41598-022-23110-2

Marine Alkaloids: Compounds with In Vivo Activity and Chemical Synthesis

Paulo E. S. Munekata, Mirian Pateiro, Carlos A. Conte-Junior, Rubén Domínguez, Asad Nawaz, Noman Walayat, Elena Movilla Fierro and José M. Lorenzo

Marine Drugs, 2021, 19, 374
DOI: 10.3390/md19070374

Aurantoside L, a New Tetramic Acid Glycoside with Anti-Leishmanial Activity Isolated from the Marine Sponge Siliquariaspongia japonica

Yasumoto Oyadomari, Yasuyuki Goto, Keisuke Suganuma, Shin-ichiro Kawazu, Leontine E. Becking, Nobuhiro Fusetani and Yoichi Nakao

Marine Drugs, 2024, 22, 171
DOI: 10.3390/md22040171

High-throughput screening identifies novel chemical scaffolds targeting Leishmania donovani parasites

Diksha Kumari, Vishwani Jamwal, Tashi Palmo, Anuj Kumar and Kuljit Singh

World J Microbiol Biotechnol, 2025, 41
DOI: 10.1007/s11274-025-04441-4

Multi-target anti-MRSA mechanism and antibiotic synergistic effect of marine alkaloid Ascomylactam A in vitro and in vivo against clinical MRSA strains

Ke-Yue Wu, Fei-Hua Yao, Xu-Meng Ren, Xu-Dong Hang, Yue-Fan Bai and Shu-Hua Qi

Biochemical Pharmacology, 2025, 232, 116697
DOI: 10.1016/j.bcp.2024.116697

Disulfide-rich polysulfur alkaloids target vascular endothelial growth factor A through electronic duality and shape-responsive recognition

Biswajit Mohanty and Parthapratim Munshi

Sci Rep, 2025, 15
DOI: 10.1038/s41598-025-28424-5

Novel Antischistosomal Drug Targets: Identification of Alkaloid Inhibitors of SmTGR via Integrated In Silico Methods

Valéria V. M. Paixão, Yria J. A. Santos, Adriana O. Fernandes, Elaine S. Conceição, Ricardo P. Rodrigues, Daniela A. Chagas-Paula, Silvio S. Dolabella and Tiago B. Oliveira

Pathogens, 2025, 14, 591
DOI: 10.3390/pathogens14060591

Discovery of sinomenine/8-Bis(benzylthio)octanoic acid hybrids as potential anti-leukemia drug candidate via mitochondrial pathway

Xiang Gao, Haonan Li, Siyu Wang, Xiaokang Long, Xuehai Guo, Huiming Hua and Dahong Li

Bioorganic & Medicinal Chemistry Letters, 2024, 97, 129545
DOI: 10.1016/j.bmcl.2023.129545

Unlocking Marine Microbial Metabolites of Sponges and Sediments as a Source of Anti‐Trypanosoma cruzi Compounds

Vanessa Albuquerque, Felipe S. Sales, Vinícius Galvão Wakui, Lucília Kato, Ulisses Pinheiro, João Henrique G. Lago and Andre Gustavo Tempone

Chemistry & Biodiversity, 2026, 23
DOI: 10.1002/cbdv.202503749

Lethal action of Licarin A derivatives in Leishmania (L.) infantum: Imbalance of calcium and bioenergetic metabolism

Erica V. de Castro Levatti, Thais A. Costa-Silva, Thiago R. Morais, João Paulo S. Fernandes, João Henrique G. Lago and Andre G. Tempone

Biochimie, 2023, 208, 141
DOI: 10.1016/j.biochi.2022.12.018

Intracellular ROS production and apoptotic effect of quinoline and isoquinoline alkaloids on the growth of Trypanosoma evansi

Ruma Rani, Khushboo Sethi, Snehil Gupta, Nitin Virmani, Sanjay Kumar and Rajender Kumar

Acta Tropica, 2023, 245, 106980
DOI: 10.1016/j.actatropica.2023.106980

Navigating drug repurposing for Chagas disease: advances, challenges, and opportunities

Exequiel O. J. Porta, Karunakaran Kalesh and Patrick G. Steel

Front. Pharmacol., 2023, 14
DOI: 10.3389/fphar.2023.1233253

Syntheses and Preliminary Biological Evaluations of the Dibromopyrrole‐Containing Marine Natural Products Agesasine A, Agesasine B, Longamide E and Various Congeners

Chengzhi Chen, Tingting Yuan, Ping Lan, Lorenzo V. White, Jing Chen and Martin G. Banwell

Eur J Org Chem, 2023, 26
DOI: 10.1002/ejoc.202300003

New Imidazolium Alkaloids with Broad Spectrum of Action from the Marine Bacterium Shewanella aquimarina

Rosa Giugliano, Gerardo Della Sala, Carmine Buonocore, Carla Zannella, Pietro Tedesco, Fortunato Palma Esposito, Costanza Ragozzino, Annalisa Chianese, Maria Vittoria Morone, Valerio Mazzella, Laura Núñez-Pons, Veronica Folliero, Gianluigi Franci, Anna De Filippis, Massimiliano Galdiero and Donatella de Pascale

Pharmaceutics, 2023, 15, 2139
DOI: 10.3390/pharmaceutics15082139

Oxidative Transformation of 2-Furylanilines into Indolin-3-ones

Ekaterina R. Nasibullina, Elena Y. Mendogralo, Anton A. Merkushev, Anton S. Makarov and Maxim G. Uchuskin

J. Org. Chem., 2024, 89, 6602
DOI: 10.1021/acs.joc.4c00359

Harnessing Phytonanotechnology to Tackle Neglected Parasitic Diseases: Focus on Chagas Disease and Malaria

Manuela García, María S. Magi and Mónica C. García

Pharmaceutics, 2025, 17, 1043
DOI: 10.3390/pharmaceutics17081043

Mitochondrial Imbalance of Trypanosoma cruzi Induced by the Marine Alkaloid 6-Bromo-2′-de-N-Methylaplysinopsin

Maiara M. Romanelli, Maiara Amaral, Fernanda Thevenard, Lucas M. Santa Cruz, Luis O. Regasini, Alvaro E. Migotto, João Henrique G. Lago and Andre G. Tempone

ACS Omega, 2022, 7, 28561
DOI: 10.1021/acsomega.2c03395

Recent approaches in nanocarrier‐based therapies for neglected tropical diseases

Ana C. Mengarda, Bruno Iles, João Paulo F. Longo and Josué de Moraes

WIREs Nanomed Nanobiotechnol, 2023, 15
DOI: 10.1002/wnan.1852

The Marine Compound Tartrolon E Targets the Asexual and Early Sexual Stages of Cryptosporidium parvum

Alexis Cotto-Rosario, Emma Y. D. Miller, Fernanda G. Fumuso, Jason A. Clement, Matthew J. Todd and Roberta M. O’Connor

Microorganisms, 2022, 10, 2260
DOI: 10.3390/microorganisms10112260

Synthesis of sinomenine derivatives with potential anti-leukemia activity

Xiang Gao, Hao-Nan Li, Peng-Ju Liu, Xiao-Kang Long, Xue-Hai Guo, Hui-Ming Hua and Da-Hong Li

Journal of Asian Natural Products Research, 2025, 27, 1819
DOI: 10.1080/10286020.2024.2327524

The therapeutic potential and application of marine alkaloids in treating breast cancer

Jing Yu, Xinmin Wang, Peixin Du and Hubing Shi