Oded Cohen, Oshra Betzer, Noy Elmaliach-Pnini, Menachem Motiei, Tamar Sadan, Moran Cohen-Berkman, Or Dagan, Aron Popovtzer, Ady Yosepovich, Hana Barhom, Shulamit Michaeli and Rachela Popovtzer

Biomater. Sci., 2021, 9, 2103
DOI: 10.1039/D0BM01735C

Precision targeting of the CNS: recent progress in brain-directed nanodrug delivery

Dinithi Senanayake, Piumika Yapa, Sanduni Dabare and Imalka Munaweera

RSC Adv., 2025, 15, 25910
DOI: 10.1039/D5RA03578C

Endocytosis of Extracellular Vesicles and Release of Their Cargo from Endosomes

Bhagyashree S. Joshi, Marit A. de Beer, Ben N. G. Giepmans and Inge S. Zuhorn

ACS Nano, 2020, 14, 4444
DOI: 10.1021/acsnano.9b10033

Three-dimensional deep regression-based light scattering imaging system for nanoscale exosome analysis

Zhuo Wang, Gao Chen, Shuanglian Wang and Xuantao Su

Biomed. Opt. Express, 2023, 14, 2055
DOI: 10.1364/BOE.483791

Recent Advances in Strategies to Combat Bacterial Drug Resistance: Antimicrobial Materials and Drug Delivery Systems

Jiaxin Yao, Pengfei Zou, Yanan Cui, Liangzhu Quan, Chunsheng Gao, Zhiping Li, Wei Gong and Meiyan Yang

Pharmaceutics, 2023, 15, 1188
DOI: 10.3390/pharmaceutics15041188

Emerging innovations on exosome-based onco-therapeutics

Xiaofeng Dai, Yongju Ye and Fule He

Front. Immunol., 2022, 13
DOI: 10.3389/fimmu.2022.865245

Exosome may be the next generation of promising cell-free vaccines

Zelan Dai, Ruiru Cai, Hong Zeng, Hailian Zhu, Youwei Dou and Shibo Sun

Human Vaccines & Immunotherapeutics, 2024, 20
DOI: 10.1080/21645515.2024.2345940

Immune regulation in neurovascular units after traumatic brain injury

Zongqi Wang and Gang Chen

Neurobiology of Disease, 2023, 179, 106060
DOI: 10.1016/j.nbd.2023.106060

Combinational antitumor strategies of exosomes as drug carriers: Mini review

Guixiu Xiao, Zihan Xu and Feng Luo

Front. Pharmacol., 2023, 13
DOI: 10.3389/fphar.2022.1107329

Exosomes as bio-inspired nanocarriers for RNA delivery: preparation and applications

Ala Amiri, Rafieh Bagherifar, Ehsan Ansari Dezfouli, Seyed Hossein Kiaie, Reza Jafari and Reihaneh Ramezani

J Transl Med, 2022, 20
DOI: 10.1186/s12967-022-03325-7

RNA therapies for CNS diseases

Valentina Di Francesco, Andy J. Chua, Di Huang, Anisha D'Souza, Alicia Yang, Benjamin S. Bleier and Mansoor M. Amiji

Advanced Drug Delivery Reviews, 2024, 208, 115283
DOI: 10.1016/j.addr.2024.115283

Systematic Identification and Comparison of the Expressed Profiles of Exosomal MiRNAs in Pigs Infected with NADC30-like PRRSV Strain

Feng Cheng, Hui Wang, Lei Zhou, Ganqiu Lan, Hanchun Yang, Lixian Wang, Ligang Wang and Jing Liang

Animals, 2023, 13, 876
DOI: 10.3390/ani13050876

Innovative drug delivery strategies to the CNS for the treatment of multiple sclerosis

Ariane Mwema, Giulio G. Muccioli and Anne des Rieux

Journal of Controlled Release, 2023, 364, 435
DOI: 10.1016/j.jconrel.2023.10.052

Bioinspired Approaches for Central Nervous System Targeted Gene Delivery

Jyotish Kumar, Afroz Karim, Ummy Habiba Sweety, Hemen Sarma, Md Nurunnabi and Mahesh Narayan

ACS Appl. Bio Mater., 2024, 7, 4975
DOI: 10.1021/acsabm.3c00842

Eradicating intracellular MRSA via targeted delivery of lysostaphin and vancomycin with mannose-modified exosomes

Xiaohong Yang, Beibei Xie, Haibo Peng, Gongming Shi, Banne Sreenivas, Jian Guo, Chenhui Wang and Yun He

Journal of Controlled Release, 2021, 329, 454
DOI: 10.1016/j.jconrel.2020.11.045

Approaches and materials for endocytosis-independent intracellular delivery of proteins

Nanxi Chen, Ye He, Mingming Zang, Youxi Zhang, Hongyan Lu, Qinfu Zhao, Siling Wang and Yikun Gao

Biomaterials, 2022, 286, 121567
DOI: 10.1016/j.biomaterials.2022.121567

Exploring the potential of exosomes in diagnosis and drug delivery for pancreatic ductal adenocarcinoma

Biaoming Xu, Yu Chen, Mingjing Peng, Jin Hai Zheng and Chaohui Zuo

Intl Journal of Cancer, 2023, 152, 110
DOI: 10.1002/ijc.34195

Stromal reprogramming in solid tumors by nanoparticles: A review

Farag M.A. Altalbawy, Uday Abdul-Reda Hussein, Suhas Ballal, Mamata Chahar, Nashwan Salah Aldeen Darwish, Suman Saini, G.V. Siva Prasad, Jasur Rizaev, Hayder Hamid Abbas Al-Anbari, Mahmood Jumaa Saud and Fadhil feez

Bioorganic Chemistry, 2025, 163, 108794
DOI: 10.1016/j.bioorg.2025.108794

Regulation of ferroptosis by noncoding RNAs: a novel promise treatment in esophageal squamous cell carcinoma

Guanen Qiao, Wenjuan Zhang and Kui Dong

Mol Cell Biochem, 2022, 477, 2193
DOI: 10.1007/s11010-022-04441-0

Engineering Biofunctional Enzyme‐Mimics for Catalytic Therapeutics and Diagnostics

Qing Tang, Sujiao Cao, Tian Ma, Xi Xiang, Hongrong Luo, Pavel Borovskikh, Raul D. Rodriguez, Quanyi Guo, Li Qiu and Chong Cheng

Adv Funct Materials, 2021, 31
DOI: 10.1002/adfm.202007475

Fate reversal: Exosome-driven macrophage rejuvenation and bacterial-responsive drug release for infection immunotherapy in diabetes

Jiaxuan Zou, Wushi Cui, Niping Deng, Congsun Li, Weinan Yang, Xiaojun Ye, Feng Yao, Tao Zhang, Jian Xiao, Chiyuan Ma, Lingfeng Wu, Dahai Dong, Jing Chen, Chengchen Guo, An Liu and Haobo Wu

Journal of Controlled Release, 2025, 382, 113730
DOI: 10.1016/j.jconrel.2025.113730

Herbal nanoparticles: a targeted approach for neurodegenerative disorder treatment

Pratikeswar Panda and Rajaram Mohapatra

Journal of Drug Targeting, 2024, 32, 1233
DOI: 10.1080/1061186X.2024.2391913

Extracellular vesicles in atherosclerosis cardiovascular disease: emerging roles and mechanisms

Haoxuan Deng, Wei Qiu, Yunyan Zhang and Junyi Hua

Front. Cardiovasc. Med., 2025, 12
DOI: 10.3389/fcvm.2025.1611557

M1 Macrophage-Derived Exosomes Loaded with Gemcitabine and Deferasirox against Chemoresistant Pancreatic Cancer

Yongmei Zhao, Yuanlin Zheng, Yan Zhu, Yi Zhang, Hongyan Zhu and Tianqing Liu

Pharmaceutics, 2021, 13, 1493
DOI: 10.3390/pharmaceutics13091493

Exosome Content–Mediated Signaling Pathways in Multiple Sclerosis

Mina Mohammadinasr, Soheila Montazersaheb, Hormoz Ayromlou, Vahid Hosseini, Ommoleila Molavi and Mohammad Saeid Hejazi

Mol Neurobiol, 2024, 61, 5404
DOI: 10.1007/s12035-023-03862-2

Mesenchymal stem cells-derived exosomes for drug delivery

Yao Sun, Guoliang Liu, Kai Zhang, Qian Cao, Tongjun Liu and Jiannan Li

Stem Cell Res Ther, 2021, 12
DOI: 10.1186/s13287-021-02629-7

Nanoformulations of Herbal Extracts in Treatment of Neurodegenerative Disorders

Seyed Zachariah Moradi, Saeideh Momtaz, Zahra Bayrami, Mohammad Hosein Farzaei and Mohammad Abdollahi

Front. Bioeng. Biotechnol., 2020, 8
DOI: 10.3389/fbioe.2020.00238

Exosomes as New Biomarkers and Drug Delivery Tools for the Prevention and Treatment of Various Diseases: Current Perspectives

Qi Liu, Shiying Li, Amandine Dupuy, Hoa le Mai, Nicolas Sailliet, Cédric Logé, J.-Michel H. Robert and Sophie Brouard

IJMS, 2021, 22, 7763
DOI: 10.3390/ijms22157763

M1 Macrophage-Derived Sonoresponsive Nanoparticles for Sonodynamic Anticancer Therapy

Sijie Chen, Jiahao Wang, Haiqin Liao, Kui Tang, Yan Xu, Long Wang and Chengcheng Niu

IJN, 2022, Volume 17, 4725
DOI: 10.2147/IJN.S381170

Boron Agent Delivery Platforms Based on Natural Products for Boron Neutron Capture Therapy

Riku Kawasaki, Yamato Miura, Nanami Kono, Seiya Fujita, Keita Yamana and Atsushi Ikeda

ChemMedChem, 2024, 19
DOI: 10.1002/cmdc.202400323

Current Understanding of Therapeutic and Diagnostic Applications of Exosomes in Pancreatic Cancer

Neda Shakerian, Aida Tafazoli, Amir Razavinia, Zahra Sadrzadeh Aghajani, Nikoo Bana, Maysam Mard-Soltani, Bahman Khalesi, Zahra Sadat Hashemi and Saeed Khalili

Pancreas, 2025, 54, e255
DOI: 10.1097/MPA.0000000000002414

Ischemia Reperfusion Injury: Opportunities for Nanoparticles

Xinlong Zang, Jingyi Zhou, Xiaoxu Zhang, Yantao Han and Xuehong Chen

ACS Biomater. Sci. Eng., 2020, 6, 6528
DOI: 10.1021/acsbiomaterials.0c01197

Engineering nano-drug biointerface to overcome biological barriers toward precision drug delivery

Saquib Waheed, Zhibin Li, Fangyingnan Zhang, Anna Chiarini, Ubaldo Armato and Jun Wu

J Nanobiotechnol, 2022, 20
DOI: 10.1186/s12951-022-01605-4

The Current Status and Future Direction of Extracellular Nano-vesicles in the Alleviation of Skin Disorders

Raziyeh Ghorbani, Simzar Hosseinzadeh, Arezo Azari, Niloofar Taghipour, Masoud Soleimani, Azam Rahimpour and Hojjat Allah Abbaszadeh

CSCR, 2024, 19, 351
DOI: 10.2174/1574888X18666230418121053

Indocyanine Green Aggregation-Induced Hypotonic Stress to Remodel Aloe Exosome-like Vesicles for Enhanced Tumor Penetration and Phototherapy

Lupeng Zeng, Wanhua Shi, Kewen Chen, Kun Wang, Yaping Dai, Xin Cheng, Shi Lu, Dandan Gao, Weiming Sun, Xi Zhang, Jing Zhang and Jinghua Chen

ACS Nano, 2025, 19, 15425
DOI: 10.1021/acsnano.4c15440

Exosomes as Drug Delivery Systems: Endogenous Nanovehicles for Treatment of Systemic Lupus Erythematosus

Ana Ortega, Olga Martinez-Arroyo, Maria J. Forner and Raquel Cortes

Pharmaceutics, 2020, 13, 3
DOI: 10.3390/pharmaceutics13010003

Exploring the role of nanomedicines for the therapeutic approach of central nervous system dysfunction: At a glance

Md. Mominur Rhaman, Md. Rezaul Islam, Shopnil Akash, Mobasharah Mim, Md. Noor alam, Eugenie Nepovimova, Martin Valis, Kamil Kuca and Rohit Sharma

Front. Cell Dev. Biol., 2022, 10
DOI: 10.3389/fcell.2022.989471

Recent advancements of nanoparticles application in cancer and neurodegenerative disorders: At a glance

Md. Mominur Rahman, Md. Rezaul Islam, Shopnil Akash, Md. Harun-Or-Rashid, Tanmay Kumar Ray, Md. Saidur Rahaman, Mahfuzul Islam, Fazilatunnesa Anika, Md. Kawser Hosain, Farjana Islam Aovi, Hassan A. Hemeg, Abdur Rauf and Polrat Wilairatana

Biomedicine & Pharmacotherapy, 2022, 153, 113305
DOI: 10.1016/j.biopha.2022.113305

Polymers in Engineering Extracellular Vesicle Mimetics: Current Status and Prospective

Xinyue Wei, Sihang Liu, Yifeng Cao, Zhen Wang and Shengfu Chen

Pharmaceutics, 2023, 15, 1496
DOI: 10.3390/pharmaceutics15051496

Repair of spinal cord injury by bone marrow mesenchymal stem cell-derived exosomes: a systematic review and meta-analysis based on rat models

Zhongduo Ye, Yukun Zheng, Ningning Li, Huaibin Zhang, Qiangqiang Li and Xiong Wang

Front. Mol. Neurosci., 2024, 17
DOI: 10.3389/fnmol.2024.1448777

Nano Architect-Based Targeted Delivery Systems for Diabetic Nephropathy: A Review

Aruna Rawat, Vikas Jhawat and Rohit Dutt

CDT, 2023, 24, 662
DOI: 10.2174/1389450124666230601163338

Extracellular vesicle mediated targeting delivery of growth differentiation factor-15 improves myocardial repair by reprogramming macrophages post myocardial injury

Tingting Xiao, Jun Wei, Dabei Cai, Yu Wang, Zhiwei Cui, Qianwen Chen, Qingqing Gu, Ailin Zou, Lipeng Mao, Boyu Chi, Yuan Ji, Qingjie Wang and Ling Sun

Biomedicine & Pharmacotherapy, 2024, 172, 116224
DOI: 10.1016/j.biopha.2024.116224

Cancer cell-derived exosome based dual-targeted drug delivery system for non-small cell lung cancer therapy

Jun Wang, Xinyi Zhu, Huijun Jiang, Minghui Ji, Yuan Wu and Jin Chen

Colloids and Surfaces B: Biointerfaces, 2024, 244, 114141
DOI: 10.1016/j.colsurfb.2024.114141

Applications of Modified Mesenchymal Stem Cells as Targeted Systems against Tumor Cells

Elsa N. Garza Treviño, Adriana G. Quiroz Reyes, Paulina Delgado Gonzalez, Juan Antonio Rojas Murillo, Jose Francisco Islas, Santiago Saavedra Alonso and Carlos A. Gonzalez Villarreal

IJMS, 2024, 25, 7791
DOI: 10.3390/ijms25147791

Natural macromolecules polysaccharide-based drug delivery systems targeting tumor necrosis factor alpha receptor for the treatment of cancer: A review

Mohammad Adnan Raza, Nousheen Khatoon, Rahnuma Parveen, V. Nirisha, Yamini Thakur, Yogita Thakur, Kumari Lata, A.S. Shifana, John Disouza, Suprit D. Saoji and Ajazuddin

International Journal of Biological Macromolecules, 2025, 318, 145145
DOI: 10.1016/j.ijbiomac.2025.145145

Nanotechnology-based drug delivery for breast cancer treatment: Current applications and future directions

Md Abdus Samad, Iftikhar Ahmad, Torki A. Zughaibi, Mohd Suhail, Syed Kashif Zaidi, Fahad A. Al-Abbasi and Shams Tabrez

European Journal of Medicinal Chemistry Reports, 2025, 14, 100268
DOI: 10.1016/j.ejmcr.2025.100268

Molecular Pathogenesis of Colorectal Cancer with an Emphasis on Recent Advances in Biomarkers, as Well as Nanotechnology-Based Diagnostic and Therapeutic Approaches

Fakhria Al-Joufi, Aseem Setia, Mounir Salem-Bekhit, Ram Sahu, Fulwah Alqahtani, Retno Widyowati and Fadilah Aleanizy

Nanomaterials, 2022, 12, 169
DOI: 10.3390/nano12010169

Exosome-based therapies for mucosal delivery

Shilpa Lekhraj Peswani Sajnani, Yunyue Zhang and Driton Vllasaliu

International Journal of Pharmaceutics, 2021, 608, 121087
DOI: 10.1016/j.ijpharm.2021.121087

Advanced Regenerative Medicine Strategies for Treatment of Perianal Fistula in Crohn’s Disease

Hojjatollah Nazari, Vahid Yaghoubi Naei, Asieh Heirani Tabasi, Abolfazl Badripour, Reza Akbari Asbagh, Mohammad Reza Keramati, Amirsina Sharifi, Behnam Behboudi, Alireza Kazemeini, Maryam Abbasi, Amir Keshvari and Seyed Mohsen Ahmadi Tafti

Inflammatory Bowel Diseases, 2022, 28, 133
DOI: 10.1093/ibd/izab151

Exosome: From biology to drug delivery

Himakshi Baruah, Anupam Sarma, Debojeet Basak and Mridusmita Das

Drug Deliv. and Transl. Res., 2024, 14, 1480
DOI: 10.1007/s13346-024-01515-y

Engineered exosomes with enriched miR-23b suppress the progression of periodontitis by reprogramming macrophages

Tianyuan Qiu, Zengguang Liu, Hugang Zhang, Jiaxin Jia, Xinxin Shao, Sihan Wang, Haobo Han, Quanshun Li and Min Hu

Colloids and Surfaces B: Biointerfaces, 2025, 255, 114947
DOI: 10.1016/j.colsurfb.2025.114947

Engineered Exosome for Drug Delivery: Recent Development and Clinical Applications

Jiaqi Tian, Zhengpu Han, Dandan Song, Yanjie Peng, Min Xiong, Zhen Chen, Shuyin Duan and Lin Zhang

IJN, 2023, Volume 18, 7923
DOI: 10.2147/IJN.S444582

Constructive strategies for drug delivery systems in antivirus disease therapy by biosafety materials

Li Wang, Zhaoshuo Wang, Lingzhi Cao and Kun Ge

Biosafety and Health, 2022, 4, 161
DOI: 10.1016/j.bsheal.2022.03.008

The diagnostic role and mechanistic functions of exosomal lncRNAs in prostate cancer

Hangsheng Zhou, Hongyuan Wan, Yanyan Feng, Lijie Zhu and Yuanyuan Mi

Clin Transl Oncol, 2022, 25, 592
DOI: 10.1007/s12094-022-02982-w

EVs Containing Host Restriction Factor IFITM3 Inhibited ZIKV Infection of Fetuses in Pregnant Mice through Trans-placenta Delivery

Xue Zou, Meng Yuan, Tongyu Zhang, Nan Zheng and Zhiwei Wu

Molecular Therapy, 2021, 29, 176
DOI: 10.1016/j.ymthe.2020.09.026

Extracellular signals regulate the biogenesis of extracellular vesicles

Yong Jin, Lele Ma, Wanying Zhang, Wen Yang, Qiyu Feng and Hongyang Wang

Biol Res, 2022, 55
DOI: 10.1186/s40659-022-00405-2

Exosomal miR-574-3p from adipose-derived mesenchymal stem modulates CRIM1/BMPs signaling to restrain chondrocytes hypertrophy and inflammatory response in knee osteoarthritis

Junfeng Kang, Lu Zhang, Lu Zhang, Nan Nan, Yang Liu and Huiqin Hao

International Immunopharmacology, 2025, 159, 114916
DOI: 10.1016/j.intimp.2025.114916

Frontiers of Neurodegenerative Disease Treatment: Targeting Immune Cells in Brain Border Regions

Senthil Kumaran Satyanarayanan, Zixu Han, Jingwei Xiao, Qiuju Yuan, Wing Ho Yung, Ya Ke, Raymond Chuen-Chung Chang, Maria Huachen Zhu, Huanxing Su, Kuan-Pin Su, Dajiang Qin and Suki Man Yan Lee

Brain, Behavior, and Immunity, 2025, 123, 483
DOI: 10.1016/j.bbi.2024.10.007

The effect of bovine milk lactoferrin-loaded exosomes (exoLF) on human MDA-MB-231 breast cancer cell line

Reihaneh Ramezani, Mozhdeh Mohammadian, Elaheh Sadat Hosseini and Mehrak Zare

BMC Complement Med Ther, 2023, 23
DOI: 10.1186/s12906-023-04045-1

The Role of Exosomes in Stemness and Neurodegenerative Diseases—Chemoresistant-Cancer Therapeutics and Phytochemicals

Narasimha M. Beeraka, Shalini H. Doreswamy, Surya P. Sadhu, Asha Srinivasan, Rajeswara Rao Pragada, SubbaRao V. Madhunapantula and Gjumrakch Aliev

IJMS, 2020, 21, 6818
DOI: 10.3390/ijms21186818

A High‐Throughput Nanofluidic Device for Exosome Nanoporation to Develop Cargo Delivery Vehicles

Rui Hao, Zitong Yu, Jing Du, Shi Hu, Chao Yuan, Hang Guo, Yi Zhang and Hui Yang

Small, 2021, 17
DOI: 10.1002/smll.202102150

Engineered mesenchymal stem cell-derived extracellular vesicles constitute a versatile platform for targeted drug delivery

Wanrong Meng, Linlin Wang, Xueyu Du, Mingzhe Xie, Fan Yang, Fei Li, Zhanxuan E. Wu, Jianguo Gan, Hongxuan Wei, Chang Cao, Shun Lu, Bangrong Cao, Longjiang Li, Ling Li and Guiquan Zhu

Journal of Controlled Release, 2023, 363, 235
DOI: 10.1016/j.jconrel.2023.09.037

Extracellular Vesicles: Diagnostic and Therapeutic Applications in Cancer

Maria Antonietta Di Bella and Simona Taverna

Biology, 2024, 13, 716
DOI: 10.3390/biology13090716

Development of a Ranibizumab Biosimilar using Bovine Milk-Derived Exosomes for the Inhibition of Corneal Neovascularization

Zhou-Nalei, Li-Yanchao, Qiao-Xinrui, Yang-Xinya, Ma-Siqi, Shi-Junfang and An-Jianbin

LDDD, 2023, 20, 1308
DOI: 10.2174/1570180819666220620103339

Potential applications of macrophages in cancer immunotherapy

Maryam Sadri, Sahel Heidari, Arezoo Faridzadeh, Mona Roozbehani, Shirin Toosi, Reihaneh Alsadat Mahmoudian, Akram Hoseinzadeh, Mohammad Taha Salmani Fard, Fahimeh Lavi Arab, Soheil Rahmani Fard and Fatemeh Faraji

Biomedicine & Pharmacotherapy, 2024, 178, 117161
DOI: 10.1016/j.biopha.2024.117161

Exosomal miRNA-based theranostics in cervical cancer: bridging diagnostics and therapy

Neha R. Raghani, Mehul R. Chorawala, Kavya Parekh, Anvesha Sharma, Omar Awad Alsaidan, Prawez Alam, Mohammad Fareed and Bhupendra Prajapati

Med Oncol, 2025, 42
DOI: 10.1007/s12032-025-02752-y

Encapsulation of Hydrophilic Compounds in Small Extracellular Vesicles: Loading Capacity and Impact on Vesicle Functions

Britta Franziska Hettich, Johannes Josua Bader and Jean‐Christophe Leroux

Adv Healthcare Materials, 2022, 11
DOI: 10.1002/adhm.202100047

Extracellular vesicles as vital players in drug delivery: a focus on clinical disease treatment

Tiangang Chen, Dan Chen, Wanting Su, Jianlan Liang, Xiangning Liu and Mingxiang Cai

Front. Bioeng. Biotechnol., 2025, 13
DOI: 10.3389/fbioe.2025.1600227

Therapeutic Engineering and Drug Loading of MSC-Exosomes for Oncological Applications

Ayşenur Memur and Pınar Özkal Baydın

Regen. Eng. Transl. Med., 2025
DOI: 10.1007/s40883-025-00449-2

Biochemistry of exosomes and their theranostic potential in human diseases

Manish Dwivedi, Diya Ghosh, Anwesha Saha, Saba Hasan, Divya Jindal, Hitendra Yadav, Anuradha Yadava and Medha Dwivedi

Life Sciences, 2023, 315, 121369
DOI: 10.1016/j.lfs.2023.121369

Bio-Inspired Nanocarriers Derived from Stem Cells and Their Extracellular Vesicles for Targeted Drug Delivery

Munire Abudurexiti, Yue Zhao, Xiaoling Wang, Lu Han, Tianqing Liu, Chengwei Wang and Zhixiang Yuan

Pharmaceutics, 2023, 15, 2011
DOI: 10.3390/pharmaceutics15072011

Acquired and intrinsic gemcitabine resistance in pancreatic cancer therapy: Environmental factors, molecular profile and drug/nanotherapeutic approaches

Milad Ashrafizadeh, Kuo Luo, Wei Zhang, Amir Reza Aref and Xianbin Zhang

Environmental Research, 2024, 240, 117443
DOI: 10.1016/j.envres.2023.117443

Exosomes as Crucial Players in Pathogenesis of Systemic Lupus Erythematosus

Yue Fei, Qi Liu, Na Peng, Guocan Yang, Ziwei Shen, Pan Hong, Shengjun Wang, Ke Rui, Dawei Cui and Lihua Duan

Journal of Immunology Research, 2022, 2022, 1
DOI: 10.1155/2022/8286498

Bioinformatics strategies for studying the molecular mechanisms of fungal extracellular vesicles with a focus on infection and immune responses

Kandasamy Saravanakumar, Sugavaneswaran Siva Santosh, MohamedAli Afaan Ahamed, Anbazhagan Sathiyaseelan, Ghazala Sultan, Navabshan Irfan, Davoodbasha Mubarak Ali and Myeong-Hyeon Wang

Briefings in Bioinformatics, 2022, 23
DOI: 10.1093/bib/bbac250

Long‐Circulating Drug‐Dye‐Based Micelles with Ultrahigh pH‐Sensitivity for Deep Tumor Penetration and Superior Chemo‐Photothermal Therapy

Cunfeng Song, Yugang Li, Tianliang Li, Yuming Yang, Zhicheng Huang, Jesús Martinez de la Fuente, Jian Ni and Daxiang Cui

Adv Funct Materials, 2020, 30
DOI: 10.1002/adfm.201906309

Development of a New Drug Delivery System from HELA-Derived Exosomes and the Effect of Docetaxel-Loaded Exosomes on Mitochondrial Apoptosis

Melike Cenik, Burcin Irem Abas, Bilge Kocabiyik, Gulen Melike Demirbolat and Ozge Cevik

J Pharm Innov, 2022, 17, 931
DOI: 10.1007/s12247-021-09566-1

Exosome-modified PLGA Microspheres for Improved Internalization into Dendritic Cells and Macrophages

Gayeon You, Youngjun Kim, Joo Hang Lee, Jihyeon Song and Hyejung Mok

Biotechnol Bioproc E, 2020, 25, 521
DOI: 10.1007/s12257-020-0008-7

Biomimetic Nanovesicle Design for Cardiac Tissue Repair

Sruti Bheri, Jessica R Hoffman, Hyun-Ji Park and Michael E Davis

Nanomedicine (Lond.), 2020, 15, 1873
DOI: 10.2217/nnm-2020-0097

Potential Novel Strategies for the Treatment of Dental Pulp-Derived Pain: Pharmacological Approaches and Beyond

Christina M. A. P. Schuh, Bruna Benso and Sebastian Aguayo

Front. Pharmacol., 2019, 10
DOI: 10.3389/fphar.2019.01068

Stem cell derived extracellular vesicles therapy for perinatal brain injury: A systematic review & meta-analysis of preclinical studies and a potential path to clinic

Xiaolin Guo, Tingting Peng, Mengru Zhong, Simian Cai, Lu He and Kaishou Xu

Brain Research Bulletin, 2025, 230, 111481
DOI: 10.1016/j.brainresbull.2025.111481

Therapeutic potential of stem cell extracellular vesicles for ischemic stroke in preclinical rodent models: a meta-analysis

Jing Zhao, Huiyin Deng, Chengfeng Xun, Chunli Chen, Zhiping Hu, Lite Ge and Zheng Jiang

Stem Cell Res Ther, 2023, 14
DOI: 10.1186/s13287-023-03270-2

Extracellular vesicles for the treatment of central nervous system diseases

Viridiane Gratpain, Ariane Mwema, Yasmine Labrak, Giulio G. Muccioli, Vincent van Pesch and Anne des Rieux

Advanced Drug Delivery Reviews, 2021, 174, 535
DOI: 10.1016/j.addr.2021.05.006

Exosomal targeting and its potential clinical application

Jiao He, Weihong Ren, Wei Wang, Wenyan Han, Lu Jiang, Dai Zhang and Mengqi Guo

Drug Deliv. and Transl. Res., 2022, 12, 2385
DOI: 10.1007/s13346-021-01087-1

Global Research Trends of Exosomes in the Central Nervous System: A Bibliometric and Visualized Analysis

Yue Zhuo, Kun Ai, Ke He, Boyu Wu, Jiaying Peng, Jing Xiang, Guanlin Zhang, Ziyuan Jiao, Ruixuan Zhou and Hong Zhang

Neurospine, 2023, 20, 507
DOI: 10.14245/ns.2244988.494

Engineered Exosomes: A Promising Vehicle in Cancer Therapy

Farkhondeh Pooresmaeil, Sahar Andi, Behnam Hasannejad-Asl, Shahla Takamoli and Azam Bolhassani

Ther. Deliv., 2023, 14, 775
DOI: 10.4155/tde-2023-0131

Bioengineered nanotechnology for nucleic acid delivery

Yang Zhang, Jing Luo, Xiran Gui, Yating Zheng, Eric Schaar, Gang Liu and Jinjun Shi

Journal of Controlled Release, 2023, 364, 124
DOI: 10.1016/j.jconrel.2023.10.034

Macrophage derived Exosomal Docetaxel (Exo-DTX) for pro-metastasis suppression: QbD driven formulation development, validation, in-vitro and pharmacokinetic investigation

Moumita Basak, Saibhargav Narisepalli, Shubham A. Salunkhe, Swasti Tiwari, Deepak Chitkara and Anupama Mittal

European Journal of Pharmaceutics and Biopharmaceutics, 2024, 195, 114175
DOI: 10.1016/j.ejpb.2024.114175

Clinical delivery of circular RNA: Lessons learned from RNA drug development

Tiana Loan Young, Kevin Chang Wang, Andrew James Varley and Bowen Li

Advanced Drug Delivery Reviews, 2023, 197, 114826
DOI: 10.1016/j.addr.2023.114826

Lymph node-targeting nanovaccines for cancer immunotherapy

Qiu Wang, Zhe Wang, Xinxin Sun, Qikun Jiang, Bingjun Sun, Zhonggui He, Shenwu Zhang, Cong Luo and Jin Sun

Journal of Controlled Release, 2022, 351, 102
DOI: 10.1016/j.jconrel.2022.09.015

A systematic review on the modifications of extracellular vesicles: a revolutionized tool of nano-biotechnology

Alok Raghav and Goo-Bo Jeong

J Nanobiotechnol, 2021, 19
DOI: 10.1186/s12951-021-01219-2

Brain Microvascular Endothelial Cell-Derived Exosomes Protect Neurons from Ischemia–Reperfusion Injury in Mice

Jin Sun, Qing Yuan, Lichen Guo, Guangxu Xiao, Tong Zhang, Bing Liang, Rongmei Yao, Yan Zhu, Yue Li and Limin Hu

Pharmaceuticals, 2022, 15, 1287
DOI: 10.3390/ph15101287

Roles for Exosomes from Various Cellular Sources in Spinal Cord Injury

Wangnan Mao, Xinghao Liu, Chen Chen, Tongfu Luo, Zheng Yan, Lianguo Wu and Zhongcheng An

Mol Neurobiol, 2025
DOI: 10.1007/s12035-025-05040-y

Phytopharmaceuticals and Herbal Approaches to Target Neurodegenerative Disorders

Anas Islam, Anuradha Mishra, Rabia Ahsan and Syed Fareha

Drug Res (Stuttg), 2023, 73, 388
DOI: 10.1055/a-2076-7939

M2 macrophage-derived extracellular vesicles ameliorate Benzalkonium Chloride-induced dry eye

Chao Yang, Qi Gao, Jing Liu, Yan Wu, Xufeng Hou, Lijuan Sun, Xuhui Zhang, Yao Lu and Yingxin Yang

Experimental Eye Research, 2024, 247, 110041
DOI: 10.1016/j.exer.2024.110041

Exosome membrane-coated nanosystems: Exploring biomedical applications in cancer diagnosis and therapy

Minmin Shao, Daniela Lopes, Joana Lopes, Satar Yousefiasl, Ana Macário-Soares, Diana Peixoto, Inês Ferreira-Faria, Francisco Veiga, João Conde, Yi Huang, Xianfeng Chen, Ana Cláudia Paiva-Santos and Pooyan Makvandi

Matter, 2023, 6, 761
DOI: 10.1016/j.matt.2023.01.012

Exosome-based delivery of RNAi leads to breast cancer inhibition

Renata Silva, Débora Ferreira and Lígia R. Rodrigues

Journal of Drug Delivery Science and Technology, 2022, 78, 103931
DOI: 10.1016/j.jddst.2022.103931

Effect of Porcine Colostral Exosomes on T Cells in the Peripheral Blood of Suckling Piglets

Hiroto Miura, Itsuki Jimbo, Machi Oda, Michiko Noguchi, Kiyonori Kawasaki, Mayuko Osada-Oka, Takamitsu Tsukahara and Ryo Inoue

Animals, 2022, 12, 2172
DOI: 10.3390/ani12172172

Extracellular vesicles derived from CD73 modified human umbilical cord mesenchymal stem cells ameliorate inflammation after spinal cord injury

Xiao Zhai, Kai Chen, Huan Yang, Bo Li, Tianjunke Zhou, Haojue Wang, Huipeng Zhou, Shaofeng Chen, Xiaoyi Zhou, Xiaozhao Wei, Yushu Bai and Ming Li

J Nanobiotechnol, 2021, 19
DOI: 10.1186/s12951-021-01022-z

Mesenchymal stem cells derived extracellular vesicles: A promising nanomedicine for drug delivery system

Jafar Rezaie, Vahid Nejati, Monireh Mahmoodi and Mahdi Ahmadi

Biochemical Pharmacology, 2022, 203, 115167
DOI: 10.1016/j.bcp.2022.115167

Mesenchymal Cell-Derived Exosomes as Novel Useful Candidates for Drug Delivery

Masoumeh Einabadi, Jafar Ai, Mohammad Kargar, Farshid Kafilzadeh, Vajihe Taghdiri Nooshabadi and Houshang Jamali

Arch Neurosci, 2020, 7
DOI: 10.5812/ans.98722

Focusing on exosomes to overcome the existing bottlenecks of CAR-T cell therapy

Si-Heng Zhang, Ling-Long Peng, Yi-Fei Chen, Yan Xu and Vahid Moradi

Inflamm Regener, 2024, 44
DOI: 10.1186/s41232-024-00358-x

Unveiling the promise: Exosomes as game‐changers in anti‐infective therapy

Vivek P. Chavda, Guanghong Luo, Rajashri Bezbaruah, Tutumoni Kalita, Anupam Sarma, Gitima Deka, Yanhong Duo, Bhrigu Kumar Das, Yesha Shah and Humzah Postwala

Exploration, 2024, 4
DOI: 10.1002/EXP.20230139

Design and Application in Delivery System of Intranasal Antidepressants

Jingying Xu, Jiangang Tao and Jidong Wang

Front. Bioeng. Biotechnol., 2020, 8
DOI: 10.3389/fbioe.2020.626882

mRNA vaccines and SiRNAs targeting cancer immunotherapy: challenges and opportunities

Zhen Lv and Yuheng Dai

Discov Onc, 2025, 16
DOI: 10.1007/s12672-025-03070-5

Cannabidiol loaded extracellular vesicles sensitize triple-negative breast cancer to doxorubicin in both in-vitro and in vivo models

Nilkumar Patel, Nagavendra Kommineni, Sunil Kumar Surapaneni, Anil Kalvala, Xuegang Yaun, Aragaw Gebeyehu, Peggy Arthur, Leanne C. Duke, Sara B. York, Arvind Bagde, David G. Meckes and Mandip Singh

International Journal of Pharmaceutics, 2021, 607, 120943
DOI: 10.1016/j.ijpharm.2021.120943

Exosomes: potential diagnostic markers and drug carriers for adenomyosis

Wen-Xiu Cheng, Shao-Bin Wei, Yang Zhou, Yu Shao and Mao-Ya Li

Front. Pharmacol., 2023, 14
DOI: 10.3389/fphar.2023.1216149

Immune-Cell-Derived Exosomes for Cancer Therapy

Yongmei Zhao, Tianqing Liu and Mengjiao Zhou

Mol. Pharmaceutics, 2022, 19, 3042
DOI: 10.1021/acs.molpharmaceut.2c00407

Potential for Therapeutic-Loaded Exosomes to Ameliorate the Pathogenic Effects of α-Synuclein in Parkinson’s Disease

David J. Rademacher

Biomedicines, 2023, 11, 1187
DOI: 10.3390/biomedicines11041187

Exosome-Based Macromolecular neurotherapeutic drug delivery approaches in overcoming the Blood-Brain barrier for treating brain disorders

Krishna Yadav, R. Vijayalakshmi, Kantrol Kumar Sahu, Pavani Sure, Kavita Chahal, Renu Yadav, Sucheta, Akhilesh Dubey, Megha Jha and Madhulika Pradhan

European Journal of Pharmaceutics and Biopharmaceutics, 2024, 199, 114298
DOI: 10.1016/j.ejpb.2024.114298

Exploring kidney disease diagnosis: Unveiling the novel prospects of exosomes as microscopic messengers

Ao Xu, Lin Wang, Jinxiang Wang, Yuqi Jiang, Xianxian, Xuankai Liao, Rubing Lin and Hongtao Yang

Bioengineering & Transla Med, 2025
DOI: 10.1002/btm2.70030

Personalized nanovaccines for treating solid cancer metastases

Tang Feng, Jia Hu, Jirui Wen, Zhiyong Qian, Guowei Che, Qinghua Zhou and Lingling Zhu

J Hematol Oncol, 2024, 17
DOI: 10.1186/s13045-024-01628-4

Engineered exosome-mediated messenger RNA and single-chain variable fragment delivery for human chimeric antigen receptor T-cell engineering

Ke Si, Zhu Dai, Zhanping Li, Zheng Ye, Bo Ding, Songwei Feng, Bo Sun, Yang Shen and Zhongdang Xiao

Cytotherapy, 2023, 25, 615
DOI: 10.1016/j.jcyt.2023.01.005

Biodistribution of Exosomes and Engineering Strategies for Targeted Delivery of Therapeutic Exosomes

Hojun Choi, Yoorim Choi, Hwa Young Yim, Amin Mirzaaghasi, Jae-Kwang Yoo and Chulhee Choi

Tissue Eng Regen Med, 2021, 18, 499
DOI: 10.1007/s13770-021-00361-0

Nano-formulation of phytochemicals to combat neurodegenerative diseases: Current and thorough strategies

Sailee Chowdhury, Garima Kumari and Tanmay Jit

Pharmacological Research - Natural Products, 2025, 7, 100249
DOI: 10.1016/j.prenap.2025.100249

Active Delivery of CRISPR System Using Targetable or Controllable Nanocarriers

Yan Lyu, Cheng Yang, Xiaomei Lyu and Kanyi Pu

Small, 2021, 17
DOI: 10.1002/smll.202005222

Exosomes for mRNA delivery: a novel biotherapeutic strategy with hurdles and hope

Cynthia Aslan, Seyed Hossein Kiaie, Naime Majidi Zolbanin, Parisa Lotfinejad, Reihaneh Ramezani, Fatah Kashanchi and Reza Jafari

BMC Biotechnol, 2021, 21
DOI: 10.1186/s12896-021-00683-w

Hybrid Milk Extracellular Vesicles as Potential Systems for Oral Delivery of siRNA

Yunyue Zhang, Xiang Luo, Ning Ding, Mona Belaid, Maya Thanou and Driton Vllasaliu

Advanced Therapeutics, 2024, 7
DOI: 10.1002/adtp.202300335

The role of mesenchymal stem cells and their exosomes in radiotherapy: A new opportunity or a potential threat

Fatemeh Zeinalzadeh, Seyedeh Nasibeh Mousavikia, Mohammad Taghi Bahreyni Toossi and Hosein Azimian

Biochimica et Biophysica Acta (BBA) - General Subjects, 2025, 1869, 130823
DOI: 10.1016/j.bbagen.2025.130823

Strategies for Engineering Exosomes and Their Applications in Drug Delivery

Mengxi Zhu, Shan Li, Sanqiang Li, Haojie Wang, Juanjuan Xu, Yili Wang and Gaofeng Liang

j biomed nanotechnol, 2021, 17, 2271
DOI: 10.1166/jbn.2021.3196

Harnessing AI for Optimizing Formulation Components in Advanced Drug Delivery Systems: Analysis of Large-Scale Screening Data

Yogesh Chaudhari

SSRN Journal, 2024
DOI: 10.2139/ssrn.4812808

The Potential for Extracellular Vesicles in Nanomedicine: A Review of Recent Advancements and Challenges Ahead

Farbod Ebrahimi, Anjali Kumari, Samaneh Ghadami, Saqer Al Abdullah and Kristen Dellinger

Advanced Biology, 2024
DOI: 10.1002/adbi.202400623

Exosomes Engineering and Their Roles as Therapy Delivery Tools, Therapeutic Targets, and Biomarkers

Nika Kučuk, Mateja Primožič, Željko Knez and Maja Leitgeb

IJMS, 2021, 22, 9543
DOI: 10.3390/ijms22179543

Unveiling Exosome Potential: Transforming Treatments for Neurodegeneration

Ankit Tiwari, Brijesh Singh, Gireesh Kumar Singh, Jairam Meena, Ashish Kumar Agrawal, Saroj Kumar and Gyan Modi

ACS Appl. Bio Mater., 2025, 8, 5406
DOI: 10.1021/acsabm.5c00096

Microglia-targeting nanotherapeutics for neurodegenerative diseases

Nanxia Zhao, Nicola L. Francis, Hannah R. Calvelli and Prabhas V. Moghe

APL Bioengineering, 2020, 4
DOI: 10.1063/5.0013178

Mesenchymal stromal cell extracellular vesicles for multiple sclerosis in preclinical rodent models: A meta-analysis

Chengfeng Xun, Huiyin Deng, Jing Zhao, Lite Ge and Zhiping Hu

Front. Immunol., 2022, 13
DOI: 10.3389/fimmu.2022.972247