Advances in deep eutectic solvents and water: applications in metal- and biocatalyzed processes, in the synthesis of APIs, and other biologically active compounds

Luciana Cicco, Giuseppe Dilauro, Filippo Maria Perna, Paola Vitale and Vito Capriati

Org. Biomol. Chem., 2021, 19, 2558
DOI: 10.1039/D0OB02491K

Synthesis of benzimidazole/triphenylamine-based compounds, evaluation of their bioactivities and an in silico study with receptor tyrosine kinases

Mani Arulkumar, Kai Yang, Neng Wang, Sakayanathan Penislusshiyan, Thayumanavan Palvannan, Karthick Ramalingam, Fuming Chen, Shi-He Luo, Yong-Jun Zhou and Zhao-Yang Wang

New J. Chem., 2022, 46, 675
DOI: 10.1039/D1NJ05073G

ZnO-NP assisted synthesis of fluorescent β-carboline C-1 tethered benzimidazole/benzothiazole/benzoxazole derivatives and assessment of their photophysical properties

Vipin Kumar, Dharmender Singh, Avijit Kumar Paul, Rahul Shrivastava and Virender Singh

New J. Chem., 2019, 43, 18304
DOI: 10.1039/C9NJ04256C

Cytotoxicity, uptake and accumulation of selenium nanoparticles and other selenium species in neuroblastoma cell lines related to Alzheimer's disease by using cytotoxicity assays, TEM and single cell-ICP-MS

David Vicente-Zurdo, Beatriz Gómez-Gómez, Iván Romero-Sánchez, Noelia Rosales-Conrado, María Eugenia León-González and Yolanda Madrid

Analytica Chimica Acta, 2023, 1249, 340949
DOI: 10.1016/j.aca.2023.340949

A Review on Benzimidazole Heterocyclic Compounds: Synthesis and Their Medicinal Activity Applications

Leqaa A. Mohammed, Mohammed Alwan Farhan, Safaa A. Dadoosh, Mustafa A. Alheety, Abdulwahhab H. Majeed, Ali Saadon Mahmood and Zaid H. Mahmoud

SynOpen, 2023, 07, 652
DOI: 10.1055/a-2155-9125

In Vitro Determination of Antileshmanial Activities of Benzimidazolium Derivatives on L. major Promastigotes and Amastigotes

Kübra Kelleci and Eda Gölebatmaz

Acta Parasit., 2023, 68, 51
DOI: 10.1007/s11686-022-00632-3

Structure-based design of novel donepezil-like hybrids for a multi-target approach to the therapy of Alzheimer's disease

Leonardo Brunetti, Rosalba Leuci, Antonio Carrieri, Marco Catto, Sara Occhineri, Giuseppe Vinci, Lucia Gambacorta, Hanna Baltrukevich, Sílvia Chaves, Antonio Laghezza, Cosimo Damiano Altomare, Paolo Tortorella, M. Amélia Santos, Fulvio Loiodice and Luca Piemontese

European Journal of Medicinal Chemistry, 2022, 237, 114358
DOI: 10.1016/j.ejmech.2022.114358

Synthesis and AChE-Inhibitory Activity of New Benzimidazole Derivatives

Ulviye Acar Cevik, Begüm Nurpelin Saglik, Serkan Levent, Derya Osmaniye, Betul Kaya Cavuşoglu, Yusuf Ozkay and Zafer Asim Kaplancikli

Molecules, 2019, 24, 861
DOI: 10.3390/molecules24050861

Deep Eutectic Solvents as Effective Reaction Media for the Synthesis of 2-Hydroxyphenylbenzimidazole-Based Scaffolds en Route to Donepezil-Like Compounds

Luca Piemontese, Roberta Sergio, Federica Rinaldo, Leonardo Brunetti, Filippo M. Perna, M. Amélia Santos and Vito Capriati

Molecules, 2020, 25, 574
DOI: 10.3390/molecules25030574

Exploiting the potential of rivastigmine-melatonin derivatives as multitarget metal-modulating drugs for neurodegenerative diseases

Inês Dias, Leo Bon, Angelika Banas`, Daniel Chavarria, Fernanda Borges, Catarina Guerreiro-Oliveira, Sandra M. Cardoso, Daniele Sanna, Eugenio Garribba, Sílvia Chaves and M. Amélia Santos

Journal of Inorganic Biochemistry, 2025, 262, 112734
DOI: 10.1016/j.jinorgbio.2024.112734

Rationally Designed Cu(I) Ligand to Prevent CuAβ-Generated ROS Production in the Alzheimer’s Disease Context

Clément Rulmont, Jean-Luc Stigliani, Christelle Hureau and Charlène Esmieu

Inorg. Chem., 2024, 63, 2340
DOI: 10.1021/acs.inorgchem.3c02693

Thioether-substituted Benzimidazolium Salts: Synthesis, Characterization, Crystal Structure, and Their Inhibitory Properties Against Acetylcholinesterase and Xanthine Oxidase

Kemal Yavuz, Samir Abbas Ali Noma, Betül Şen, Tugba Taskin-Tok, Aydın Aktaş, Burhan Ateş, Bilgen Osman, Muhittin Aygün and Yetkin Gök

Journal of Molecular Structure, 2023, 1287, 135640
DOI: 10.1016/j.molstruc.2023.135640

Rivastigmine–Benzimidazole Hybrids as Promising Multitarget Metal-Modulating Compounds for Potential Treatment of Neurodegenerative Diseases

David Vicente-Zurdo, Leonardo Brunetti, Luca Piemontese, Beatriz Guedes, Sandra M. Cardoso, Daniel Chavarria, Fernanda Borges, Yolanda Madrid, Sílvia Chaves and M. Amélia Santos

IJMS, 2023, 24, 8312
DOI: 10.3390/ijms24098312

Bimetallic Cu–Ni Nanometal Supported over Mesocellular Silica Foam As a Novel Catalyst for One-Pot Synthesis of Benzimidazole in DMF As a Bifunctional Reagent

Shalaka S. Mohire and Ganapati D. Yadav

Ind. Eng. Chem. Res., 2022, 61, 6909
DOI: 10.1021/acs.iecr.2c01344

Exploring the Benzazoles Derivatives as Pharmacophores for AChE, BACE1, and as Anti-Aβ Aggregation to Find Multitarget Compounds against Alzheimer’s Disease

Martha Cecilia Rosales Hernández, Marycruz Olvera-Valdez, Jazziel Velazquez Toledano, Jessica Elena Mendieta Wejebe, Leticia Guadalupe Fragoso Morales and Alejandro Cruz

Molecules, 2024, 29, 4780
DOI: 10.3390/molecules29194780

Donepezil-based hybrids as multifunctional anti-Alzheimer's disease chelating agents: Effect of positional isomerization

Marina Costa, Romane Josselin, Diana F. Silva, Sandra M. Cardoso, Nóra V. May, Sílvia Chaves and M. Amélia Santos

Journal of Inorganic Biochemistry, 2020, 206, 111039
DOI: 10.1016/j.jinorgbio.2020.111039

2-Benzimidazolamine-Acetamide Derivatives as Antibacterial Agents: Synthesis, ADMET, Molecular Docking, and Molecular Simulation Studies

Ayesha Akhtar, Asghar Ali, Kashish Azeem, Mohammad Abid, Nasreen Akhtar Mazumdar and Afreen Inam

Synthesis, 2025, 57, 637
DOI: 10.1055/s-0043-1775413

Novel Rivastigmine Derivatives as Promising Multi-Target Compounds for Potential Treatment of Alzheimer’s Disease

David Vicente-Zurdo, Noelia Rosales-Conrado, M. Eugenia León-González, Leonardo Brunetti, Luca Piemontese, A. Raquel Pereira-Santos, Sandra M. Cardoso, Yolanda Madrid, Sílvia Chaves and M. Amélia Santos

Biomedicines, 2022, 10, 1510
DOI: 10.3390/biomedicines10071510

Importance of Biometals as Targets in Medicinal Chemistry: An Overview about the Role of Zinc (II) Chelating Agents

Rosalba Leuci, Leonardo Brunetti, Antonio Laghezza, Fulvio Loiodice, Paolo Tortorella and Luca Piemontese

Applied Sciences, 2020, 10, 4118
DOI: 10.3390/app10124118

Role of copper chelating agents: between old applications and new perspectives in neuroscience

Rosalba Leuci, Leonardo Brunetti, Vincenzo Tufarelli, Marco Cerini, Marco Paparella, Nikola Puvača and Luca Piemontese

Neural Regeneration Research, 2025, 20, 751
DOI: 10.4103/NRR.NRR-D-24-00140

Design, Synthesis, and In Vitro Evaluation of Hydroxybenzimidazole-Donepezil Analogues as Multitarget-Directed Ligands for the Treatment of Alzheimer’s Disease

Sílvia Chaves, Simonetta Resta, Federica Rinaldo, Marina Costa, Romane Josselin, Karolina Gwizdala, Luca Piemontese, Vito Capriati, A. Raquel Pereira-Santos, Sandra M. Cardoso and M. Amélia Santos

Molecules, 2020, 25, 985
DOI: 10.3390/molecules25040985

Role of Metal Cations of Copper, Iron, and Aluminum and Multifunctional Ligands in Alzheimer’s Disease: Experimental and Computational Insights

Nicolás Puentes-Díaz, Diego Chaparro, David Morales-Morales, Areli Flores-Gaspar and Jorge Alí-Torres

ACS Omega, 2023, 8, 4508
DOI: 10.1021/acsomega.2c06939

Benzimidazole-derived Compounds Designed for Different Targets of Alzheimer’s Disease

Hayrettin Ozan Gulcan, Açelya Mavideniz, Mustafa Fethi Sahin and Ilkay Erdogan Orhan

CMC, 2019, 26, 3260
DOI: 10.2174/0929867326666190124123208

Rivastigmine structure-based hybrids as potential multi-target anti-Alzheimer’s drug candidates

Rosalba Leuci, Stefan Simic, Antonio Carrieri, Sílvia Chaves, Gabriella La Spada, Leonardo Brunetti, Paolo Tortorella, Fulvio Loiodice, Antonio Laghezza, Marco Catto, M.Amélia Santos, Vincenzo Tufarelli, Judith Wackerlig and Luca Piemontese

Bioorganic Chemistry, 2024, 153, 107895
DOI: 10.1016/j.bioorg.2024.107895