Generating linear oxygen gradients across 3D cell cultures with block-layered oxygen controlled chips (BLOCCs)

Matthew W. Boyce, William C. Simke, Rachael M. Kenney and Matthew R. Lockett

Anal. Methods, 2020, 12, 18
DOI: 10.1039/C9AY01690B

Oxygen control: the often overlooked but essential piece to create betterin vitrosystems

Valentina Palacio-Castañeda, Niels Velthuijs, Séverine Le Gac and Wouter P. R. Verdurmen

Lab Chip, 2022, 22, 1068
DOI: 10.1039/D1LC00603G

Supported gel slab scaffolds as a three-dimensional cell-based assay platform

Zachary R. Sitte, Elizabeth E. Karlsson, Tyler S. Larson, Haolin Li, Haibo Zhou and Matthew R. Lockett

Analyst, 2024, 149, 4653
DOI: 10.1039/D4AN00691G

Development of a stacked, porous silk scaffold neuroblastoma model for investigating spatial differences in cell and drug responsiveness

Kimberly J. Ornell, Katelyn S. Mistretta, Coulter Q. Ralston and Jeannine M. Coburn

Biomater. Sci., 2021, 9, 1272
DOI: 10.1039/D0BM01153C

Assessing chemotherapeutic effectiveness using a paper-based tumor model

Matthew W. Boyce, Gabriel J. LaBonia, Amanda B. Hummon and Matthew R. Lockett

Analyst, 2017, 142, 2819
DOI: 10.1039/C7AN00806F

3D cellular invasion platforms: how do paper-based cultures stack up?

Rachael M. Kenney, C. Chad Lloyd, Nathan A. Whitman and Matthew R. Lockett

Chem. Commun., 2017, 53, 7194
DOI: 10.1039/C7CC02357J

Selecting the appropriate indirect viability assay for 3D paper-based cultures: a data-driven study

Zachary R. Sitte, Tyler S. Larson, Julie C. McIntosh, Melanie Sinanian and Matthew R. Lockett

Analyst, 2023, 148, 2245
DOI: 10.1039/D3AN00283G

Screening Estrogen Receptor Modulators in a Paper-Based Breast Cancer Model

Nathan A. Whitman, Zhi-Wei Lin, Thomas J. DiProspero, Julie C. McIntosh and Matthew R. Lockett

Anal. Chem., 2018, 90, 11981
DOI: 10.1021/acs.analchem.8b02486

Developing a Drug Screening Platform: MALDI-Mass Spectrometry Imaging of Paper-Based Cultures

Fernando Tobias, Julie C. McIntosh, Gabriel J. LaBonia, Matthew W. Boyce, Matthew R. Lockett and Amanda B. Hummon

Anal. Chem., 2019, 91, 15370
DOI: 10.1021/acs.analchem.9b03536

Paper-Based Cell Culture: Paving the Pathway for Liver Tissue Model Development on a Cellulose Paper Chip

Tarun Agarwal, Mimi R. Borrelli, Pooyan Makvandi, Milad Ashrafizadeh and Tapas Kumar Maiti

ACS Appl. Bio Mater., 2020, 3, 3956
DOI: 10.1021/acsabm.0c00558

Cellular Invasion Assay for the Real-Time Tracking of Individual Cells in Spheroid or Tumor-like Mimics

Rachael M. Kenney, Maggie C. Lee, Matthew W. Boyce, Zachary R. Sitte and Matthew R. Lockett

Anal. Chem., 2023, 95, 3054
DOI: 10.1021/acs.analchem.2c05201

Hypoxia differentially regulates estrogen receptor alpha in 2D and 3D culture formats

Nathan A. Whitman, Zhi-Wei Lin, Rachael M. Kenney, Leonardo Albertini and Matthew R. Lockett

Archives of Biochemistry and Biophysics, 2019, 671, 8
DOI: 10.1016/j.abb.2019.05.025

Dual Cross‐Linked Biofunctional and Self‐Healing Networks to Generate User‐Defined Modular Gradient Hydrogel Constructs

Zhao Wei, Daniel M. Lewis, Yu Xu and Sharon Gerecht

Adv Healthcare Materials, 2017, 6
DOI: 10.1002/adhm.201700523

Developing novel in vitro methods for the risk assessment of developmental and placental toxicants in the environment

Rebecca C. Fry, Jacqueline Bangma, John Szilagyi and Julia E. Rager

Toxicology and Applied Pharmacology, 2019, 378, 114635
DOI: 10.1016/j.taap.2019.114635

Selective induction of sprouting and intussusception is associated with the concentration distributions of oxygen and hypoxia-induced VEGF

Kuihua Zhan, Lun Bai and Qi Hu

Microvascular Research, 2020, 132, 104041
DOI: 10.1016/j.mvr.2020.104041

A three-zone hypoxia chamber capable of regulating unique oxygen and carbon dioxide partial pressures simultaneously

Zachary R. Sitte, Abel A. Miranda, Thomas J. DiProspero and Matthew R. Lockett

HardwareX, 2024, 19, e00556
DOI: 10.1016/j.ohx.2024.e00556

Circular Patterns of Dynamic Covalent Hydrogels with Gradient Stiffness for Screening of the Stem Cell Microenvironment

Qimeng Wang, Ziyan Wang, Difei Zhang, Jieyu Gu, Yongxin Ma, Yan Zhang and Jinghua Chen

ACS Appl. Mater. Interfaces, 2022, 14, 47461
DOI: 10.1021/acsami.2c14924

Three-Dimensional, Scaffolded Tumor Model to Study Cell-Driven Microenvironment Effects and Therapeutic Responses

Kimberly J. Ornell, Katelyn S. Mistretta, Emily Newman, Coulter Q. Ralston and Jeannine M. Coburn

ACS Biomater. Sci. Eng., 2019, 5, 6742
DOI: 10.1021/acsbiomaterials.9b01267

Paper‐based Invasion Assays for Quantifying Cellular Movement in Three‐dimensional Tissue‐like Structures

C. Chad Lloyd, Matthew W. Boyce and Matthew R. Lockett

CP Chemical Biology, 2017, 9, 75
DOI: 10.1002/cpch.22

Spatially resolved quantification of drug metabolism and efficacy in 3D paper-based tumor mimics

Tyler S. Larson, Gary L. Glish and Matthew R. Lockett

Analytica Chimica Acta, 2021, 1186, 339091
DOI: 10.1016/j.aca.2021.339091

A pH-Sensing Optode for Mapping Spatiotemporal Gradients in 3D Paper-Based Cell Cultures

Rachael M. Kenney, Matthew W. Boyce, Nathan A. Whitman, Brenden P. Kromhout and Matthew R. Lockett

Anal. Chem., 2018, 90, 2376
DOI: 10.1021/acs.analchem.7b05015

Editors’ Choice—Luminescent Oxygen Sensors: Valuable Tools for Spatiotemporal Exploration of Metabolism in In Vitro Systems

Tyler Z. Sodia and Kevin J. Cash

ECS Sens. Plus, 2023, 2, 032401
DOI: 10.1149/2754-2726/ace202

A Hybrid Nanofiber/Paper Cell Culture Platform for Building a 3D Blood–Brain Barrier Model

Kaixiang Huang, Andre D. Castiaux, Ram Podicheti, Douglas B. Rusch, R. Scott Martin and Lane A. Baker

Small Methods, 2021, 5
DOI: 10.1002/smtd.202100592

Tissue Papers: Leveraging Paper-Based Microfluidics for the Next Generation of 3D Tissue Models

Sabrina M. Cramer, Tyler S. Larson and Matthew R. Lockett

Anal. Chem., 2019, 91, 10916
DOI: 10.1021/acs.analchem.9b02102