Cobalt-catalyzed regio-and stereoselective synthesis of atropisomers with vicinal C-C and C-N diaxes

Abstract

A regio-, diastereo-, and enantioselective cobalt-catalyzed C-H activation/annulation of aromatic and alkenyl amides has been developed to access heterocycles featuring vicinal C-C and C-N diaxes. This strategy uniquely harnesses previously unexplored electronically unbiased internal alkynes and proceeds under mild conditions to deliver products in high yields with excellent regio- and stereocontrol.