Francesca Collu, Enrico Spiga, Nesrine Chakroun, Human Rezaei and Franca Fraternali
Chem. Commun., 2018,54, 8007-8010
DOI:
10.1039/C8CC04089C,
Communication
Prions are self-replicating infectious proteinaceous agents whose conformations are capable of forming amyloid-like aggregate fibrils. Here we present molecular dynamics simulations aimed at investigating the aggregation process of the β-rich H2H3 domain of the ovine prion protein (H2H3-OvPrPSc), known to be the portion of prion protein carrying oligomerization activity.
