From the journal:

Chemical Communications

AIE Ir(iii) complex conjugated with biotin as a photosensitizer for enhanced photodynamic anticancer therapy

Zihan Wu,†a   Runlin Wang,†a   Chunguang Shi,a   Dongxia Zhu ORCID logo *a  and  Martin R. Bryce ORCID logo *b  

* Corresponding authors

a Key Laboratory of Nanobiosensing and Nanobioanalysis at Universities of Jilin Province, Department of Chemistry, Northeast Normal University, 5268 Renmin Street, Changchun, Jilin Province 130024, P. R. China
E-mail: zhudx047@nenu.edu.cn

b Department of Chemistry, Durham University, Durham, UK
E-mail: m.r.bryce@durham.ac.uk

Abstract

The first aggregation induced emission (AIE) Ir(III) complex bearing a biotin-functionalized ligand, Ir-Bio, is reported. Ir-Bio generates type I and type II reactive oxygen species and has an excellent photodynamic therapy effect in cancer cells.

Graphical abstract: AIE Ir(iii) complex conjugated with biotin as a photosensitizer for enhanced photodynamic anticancer therapy

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Article information

DOI
https://doi.org/10.1039/D5CC04806K
Article type
Communication
Submitted
20 Aug 2025
Accepted
03 Oct 2025
First published
13 Oct 2025
This article is Open Access
Creative Commons BY license

Chem. Commun., 2025, Advance Article

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AIE Ir(III) complex conjugated with biotin as a photosensitizer for enhanced photodynamic anticancer therapy

Z. Wu, R. Wang, C. Shi, D. Zhu and M. R. Bryce, Chem. Commun., 2025, Advance Article , DOI: 10.1039/D5CC04806K

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