Issue 57, 2025

A fluorescent molecular rotor for biomolecular imaging analysis

Abstract

Biological macromolecules play a crucial role in information transmission, energy storage and structural support, and are closely related to the physiological state of living organisms. Disruption of the macromolecular homeostasis or anomalies of cellular microenvironment can precipitate cellular dysfunction, potentially leading to a spectrum of diseases including diabetes, neurodegenerative disorders, inflammatory conditions, and cancer. Consequently, aberrations in biological macromolecules have emerged as pivotal biomarkers linked to a myriad of diseases. Fluorescent molecular rotors play an essential role in imaging and analyzing biomarkers of biological macromolecules in living cells. When the rotation of fluorescent molecular rotors is restricted within biological macromolecules, the fluorescence of the probe is turned on, serving the purpose of imaging analysis. This article reviews the design principles of fluorescent molecular rotors, focusing on their application in the imaging analysis of biological macromolecules such as proteins, nucleic acids, and lipids. By elucidating their mechanisms of action and applications, it is hoped to pave a new avenue of research for researchers in various fields.

Graphical abstract: A fluorescent molecular rotor for biomolecular imaging analysis

Article information

Article type
Highlight
Submitted
23 Май 2025
Accepted
17 Июнь 2025
First published
18 Июнь 2025

Chem. Commun., 2025,61, 10408-10417

A fluorescent molecular rotor for biomolecular imaging analysis

D. Xie, S. Sun, Q. Zhou, C. Wang, L. Cao, W. Zhang and G. Li, Chem. Commun., 2025, 61, 10408 DOI: 10.1039/D5CC02923F

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements