Alexandra Fillion, Jaime Franco Pinto and Anton Granzhan
Org. Biomol. Chem., 2022,20, 1888-1892
DOI:
10.1039/D2OB00208F,
Communication
The fluorescence properties of an emissive guanine surrogate, thienoguanine (thGN, 2-aminothieno[3,4-d]pyrimidin-4(3H)-one), were exploited to design two real-time chemosensors of O6-methylguanine-DNA-methyltransferase (MGMT), a key DNA repair enzyme involved in the resistance to DNA-alkylating anti-cancer drugs though direct reversal of O6-alkylated guanine adducts.