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Abstract | Cited by

The design and synthesis of amphiphilic benzoylurea α-helix mimetics is described. These conformationally constrained molecules allow for the correct angular and spatial projection of hydrophobic and hydrophilic groups and thus the reproduction of side-chains on both faces of an α-helix.

Graphical abstract: Amphiphilic α-helix mimetics based on a benzoylurea scaffold

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