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Regioselective synthesis of halohydrin esters was achieved by (1) the reaction of acyl halides with epoxides and (2) the rhodium-catalyzed three-component coupling reaction of alkyl halides, carbon monoxide, and epoxides.

Graphical abstract: Regioselective synthesis of halohydrin esters from epoxides: reaction with acyl halides and rhodium-catalyzed three-component coupling reaction with alkyl halides and carbon monoxide

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