Three-component copper-catalyzed difluoroalkylamidation of alkynes: an efficient approach to difluoroalkylated enamides

Abstract

This paper describes a selective three-component 1,2-difluoroalkylamidation of alkynes enabled by a coordinating activation strategy. This protocol utilizes commercially available difluoroalkyl halides as radical precursors and picolinamides as nitrogen sources, facilitating the synthesis of difluoroalkylated enamides with broad substrate scope, good functional group compatibility, and exceptional stereoselectivity. The modular catalytic synthesis is characterized by its ease of implementation, broad molecular diversity, and flexibility in late-stage modifications.