Activity Models of Key GPCR Families in the Central Nervous System: A Tool for Many Purposes

Shayma El-Atawneh and Amiram Goldblum

J. Chem. Inf. Model., 2023, 63, 3248
DOI: 10.1021/acs.jcim.2c01531

Molecular Tools to Study and Control Dopaminergic Neurotransmission With Light

Galyna Maleeva, Carlo Matera, Silvia Roda, Alessio Colleoni, Marco De Amici and Pau Gorostiza

Medicinal Research Reviews, 2025, 45, 1407
DOI: 10.1002/med.22112

Determinants of Neutral Antagonism and Inverse Agonism in the β2-Adrenergic Receptor

Jacqueline C. Calderón, Passainte Ibrahim, Dorothea Gobbo, Francesco Luigi Gervasio and Timothy Clark

J. Chem. Inf. Model., 2024, 64, 2045
DOI: 10.1021/acs.jcim.3c01763

Isolation and functional identification of secretin family G-protein coupled receptor from Y-organ of the mud crab, Scylla olivacea

Sirinart Techa, Wilawan Thongda, Phimsucha Bunphimpapha, Wanwipa Ittarat, Manon Boonbangyang, Alisa Wilantho, Chumpol Ngamphiw, Boonyarath Pratoomchat, Prachumporn Nounurai and Sanit Piyapattanakorn

Gene, 2023, 848, 146900
DOI: 10.1016/j.gene.2022.146900

Expression of G protein-coupled receptor GPR19 in normal and neoplastic human tissues

Lorena Gerlach, Anna-Sophia Liselott Beyer, Daniel Kaemmerer, Jörg Sänger, Katja Evert, Stefan Schulz and Amelie Lupp

Sci Rep, 2023, 13
DOI: 10.1038/s41598-023-46395-3

Ligand-Dependent and G Protein-Dependent Properties for the Sweet Taste Heterodimer, TAS1R2/1R3

Soo-Kyung Kim, Brian Guthrie and William A. Goddard

J. Phys. Chem. B, 2024, 128, 8927
DOI: 10.1021/acs.jpcb.4c04610

The Application of Artificial Intelligence Accelerates G Protein-Coupled Receptor Ligand Discovery

Wei Chen, Chi Song, Liang Leng, Sanyin Zhang and Shilin Chen

Engineering, 2024, 32, 18
DOI: 10.1016/j.eng.2023.09.011

A Bright Future? A Perspective on Class C GPCR Based Genetically Encoded Biosensors

Margulan Otanuly, Martin Kubitschke and Olivia Andrea Masseck

ACS Chem. Neurosci., 2024, 15, 889
DOI: 10.1021/acschemneuro.3c00854

The GPR35 expression pattern is associated with overall survival in male patients with colorectal cancer

Tomasz Mackiewicz, Damian Jacenik, Marcin Talar and Jakub Fichna

Pharmacol. Rep, 2022, 74, 709
DOI: 10.1007/s43440-022-00371-2

GPR27 Regulates Hepatocellular Carcinoma Progression via MAPK/ERK Pathway

Hongxv Wang, Danyu Du, Jianwen Huang, Shuai Wang, Xv He, Shengtao Yuan and Jing Xiao

CMAR, 2022, Volume 14, 1165
DOI: 10.2147/CMAR.S335749

Essential Dynamics Ensemble Docking for Structure-Based GPCR Drug Discovery

Kyle McKay, Nicholas B. Hamilton, Jacob M. Remington, Severin T. Schneebeli and Jianing Li

Front. Mol. Biosci., 2022, 9
DOI: 10.3389/fmolb.2022.879212

Genome-wide identification and functional characterization of GPCR family genes reveal their key roles in the vitellarium development and egg production in Schistosoma japonicum

Xiaoxu Wang, Chuantao Fang and Guofeng Cheng

Parasites Vectors, 2025, 18
DOI: 10.1186/s13071-025-06929-2

Mechanistic Understanding from Molecular Dynamics in Pharmaceutical Research 2: Lipid Membrane in Drug Design

Tomasz Róg, Mykhailo Girych and Alex Bunker

Pharmaceuticals, 2021, 14, 1062
DOI: 10.3390/ph14101062

Rhodopsin orphan GPCR20 interacts with neuropeptides and directs growth, sexual differentiation, and egg production in female Schistosoma mansoni

Xuesong Li, Oliver Weth, Martin Haimann, Max F. Möscheid, Theresa S. Huber, Christoph G. Grevelding and Mostafa Zamanian

Microbiol Spectr, 2024, 12
DOI: 10.1128/spectrum.02193-23

Stringent in-silico identification of putative G-protein-coupled receptors (GPCRs) of the entomopathogenic nematode Heterorhabditis bacteriophora

Artha Kundu, Nisha Jaiswal, Uma Rao and Vishal Singh Somvanshi

Journal of Nematology, 2023, 55
DOI: 10.2478/jofnem-2023-0038

Beneficial effects of dietary supplementation with green tea catechins and cocoa flavanols on aging-related regressive changes in the mouse neuromuscular system

Sílvia Gras, Alba Blasco, Guillem Mòdol-Caballero, Olga Tarabal, Anna Casanovas, Lídia Piedrafita, Alejandro Barranco, Tapas Das, Ricardo Rueda, Suzette L. Pereira, Xavier Navarro, Josep E. Esquerda and Jordi Calderó

Aging, 2021, 13, 18051
DOI: 10.18632/aging.203336

G protein-coupled receptors in cochlea: Potential therapeutic targets for hearing loss

Xiangyu Ma, Jiamin Guo, Yaoyang Fu, Cangsong Shen, Pei Jiang, Yuan Zhang, Lei Zhang, Yafeng Yu, Jiangang Fan and Renjie Chai

Front. Mol. Neurosci., 2022, 15
DOI: 10.3389/fnmol.2022.1028125

3DDPDs: describing protein dynamics for proteochemometric bioactivity prediction. A case for (mutant) G protein-coupled receptors

Marina Gorostiola González, Remco L. van den Broek, Thomas G. M. Braun, Magdalini Chatzopoulou, Willem Jespers, Adriaan P. IJzerman, Laura H. Heitman and Gerard J. P. van Westen

J Cheminform, 2023, 15
DOI: 10.1186/s13321-023-00745-5

A Comprehensive Analysis of Fibromyalgia and the Role of the Endogenous Opioid System

Mario García-Domínguez

Biomedicines, 2025, 13, 165
DOI: 10.3390/biomedicines13010165

Inhibitory effect of truncated isoforms on GPCR dimerization predicted by combinatorial computational strategy

Mengke Li, Rui Qing, Fei Tao, Ping Xu and Shuguang Zhang

Computational and Structural Biotechnology Journal, 2024, 23, 278
DOI: 10.1016/j.csbj.2023.12.008

Protons taken hostage: Dynamic H-bond networks of the pH-sensing GPR68

Bhav Kapur, Filippo Baldessari, Michalis Lazaratos, Herbert Nar, Gisela Schnapp, Alejandro Giorgetti and Ana-Nicoleta Bondar

Computational and Structural Biotechnology Journal, 2023, 21, 4370
DOI: 10.1016/j.csbj.2023.08.034

Electron Donor–Acceptor Properties of Different Muscarinic Ligands: On the Road to Control Schizophrenia

Guillermo Goode-Romero, Laura Dominguez and Ana Martínez

J. Chem. Inf. Model., 2021, 61, 5117
DOI: 10.1021/acs.jcim.1c00780

Insights into the structural dynamics of the secretin family (class B1) G protein-coupled receptors

Ting Liu, Narisa Ria Naidoo, Eugene Agyemang and Rajan Lamichhane

Journal of Biological Chemistry, 2025, 301, 110466
DOI: 10.1016/j.jbc.2025.110466

Recent Advances in Cell Membrane-Coated Technology for Drug Discovery from Natural Products

Yusi Bu, Qi Hu, Tao Bao, Xiaoyu Xie and Sicen Wang

SSRN Journal, 2022
DOI: 10.2139/ssrn.4021955

Potential Therapeutic Exploitation of G Protein-Coupled Receptor 120 (GPR120/FFAR4) Signaling in Obesity-Related Metabolic Disorders

Dariusz Szukiewicz

IJMS, 2025, 26, 2501
DOI: 10.3390/ijms26062501

Recent advances in cell membrane-coated technology for drug discovery from natural products

Yusi Bu, Qi Hu, Tao Bao, Xiaoyu Xie and Sicen Wang

TrAC Trends in Analytical Chemistry, 2022, 151, 116601
DOI: 10.1016/j.trac.2022.116601

Phospholipid Scrambling by G Protein–Coupled Receptors

George Khelashvili and Anant K. Menon

Annu. Rev. Biophys., 2022, 51, 39
DOI: 10.1146/annurev-biophys-090821-083030

Methuselah proteins in Drosophila: Structural and evolutionary insights from mathematical genomics

Sk Sarif Hassan, Debaleena Nawn, Ankita Ghosh, Moumita Sil, Arunava Goswami, Pallab Basu, Kenneth Lundstrom and Vladimir N. Uversky

Biochemical and Biophysical Research Communications, 2025, 777, 152240
DOI: 10.1016/j.bbrc.2025.152240

Distinct activation mechanisms regulate subtype selectivity of Cannabinoid receptors

Soumajit Dutta and Diwakar Shukla

Commun Biol, 2023, 6
DOI: 10.1038/s42003-023-04868-1

On the Rational Drug Design for Hypertension through NMR Spectroscopy

Eleni Chontzopoulou, Andreas G. Tzakos and Thomas Mavromoustakos

Molecules, 2020, 26, 12
DOI: 10.3390/molecules26010012

The Many Faces of G Protein-Coupled Receptor 143, an Atypical Intracellular Receptor

Beatriz Bueschbell, Prashiela Manga and Anke C. Schiedel

Front. Mol. Biosci., 2022, 9
DOI: 10.3389/fmolb.2022.873777

Volatile Short-Chain Aliphatic Aldehydes Act as Taste Modulators through the Orally Expressed Calcium-Sensing Receptor CaSR

Seiji Kitajima, Yutaka Maruyama and Motonaka Kuroda

Molecules, 2023, 28, 4585
DOI: 10.3390/molecules28124585

Engineered Human Antibody with Improved Endothelin Receptor Type A Binding Affinity, Developability, and Serum Persistence Exhibits Excellent Antitumor Potency

Sanghwan Ko, Man-Seok Ju, Hye-Mi Ahn, Jung-Hyun Na, Woo Hyung Ko, Migyeong Jo, Munsu Kyung, Chung Su Lim, Byoung Joon Ko, Won-Kyu Lee, Youn-Jae Kim and Sang Taek Jung

Mol. Pharmaceutics, 2023, 20, 1247
DOI: 10.1021/acs.molpharmaceut.2c00923