Nanoparticles constructed from natural polyphenols are used in acute kidney injury

Abstract

Acute kidney injury is a severe clinical syndrome characterized by rapid deterioration of renal function caused by a variety of pathogeneses. Natural polyphenols have been considered to have potential in the treatment of AKI due to their powerful antioxidant and anti-inflammatory activities, but their low bioavailability in vivo limits their efficacy. Polyphenol nanoparticles based on nano-delivery system show good effect in reducing kidney injury, improving renal function and promoting renal tissue repair. It brings new hope and possibility for the treatment of acute kidney injury. This review provides an overview of the common characteristics, treatments, and associated adverse effects of acute kidney injury. The classification and bioavailability of polyphenols as well as their therapeutic role in acute kidney injury and potential possible effects are outlined. The potential therapeutic effects of polyphenol-based nanoparticles on AKI and the underlying mechanisms are discussed.