Issue 4, 2018

Nickel-catalyzed direct difluoromethylation of aryl boronic acids with BrCF2H

Abstract

A nickel-catalyzed direct difluoromethylation of aryl boronic acids has been developed for the first time, demonstrating good efficiency, mild conditions, and good functional-group compatibility. The key to success is the combination of different kinds of readily available nitrogen and phosphine ligands with a nickel source, which can generate a variety of easily tunable catalysts in situ to promote the difluoromethylation of a broad scope of aryl boronic acids.

Graphical abstract: Nickel-catalyzed direct difluoromethylation of aryl boronic acids with BrCF2H

Supplementary files

Article information

Article type
Research Article
Submitted
13 Onk 2017
Accepted
31 Onk 2017
First published
01 Sad 2017

Org. Chem. Front., 2018,5, 606-610

Nickel-catalyzed direct difluoromethylation of aryl boronic acids with BrCF2H

J. Sheng, H. Ni, K. Bian, Y. Li, Y. Wang and X. Wang, Org. Chem. Front., 2018, 5, 606 DOI: 10.1039/C7QO00934H

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements