Issue 12, 2017

Gold-catalyzed diversified synthesis of 3-aminosugar analogues of digitoxin and digoxin

Abstract

A diversified synthesis of 3-aminosugar analogues of digitoxin and digoxin with potent anticancer activities was explored. The synthesis was based on a highly efficient gold-catalyzed glycosylation reaction with alkynylbenzoate 3-aminoglycosides as glycosyl donors. According to this strategy, a small library containing digitoxin and digoxin analogues with various 3-aminosugar scaffolds was successfully constructed.

Graphical abstract: Gold-catalyzed diversified synthesis of 3-aminosugar analogues of digitoxin and digoxin

Supplementary files

Article information

Article type
Research Article
Submitted
28 Ado 2017
Accepted
05 Ful 2017
First published
06 Ful 2017

Org. Chem. Front., 2017,4, 2450-2454

Gold-catalyzed diversified synthesis of 3-aminosugar analogues of digitoxin and digoxin

J. Zeng, G. Sun, R. Wang, S. Zhang, S. Teng, Z. Liao, L. Meng and Q. Wan, Org. Chem. Front., 2017, 4, 2450 DOI: 10.1039/C7QO00648A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements