Andrew J. Counsell, Stephen J. Walsh, Naomi S. Robertson, Hannah F. Sore and David R. Spring
Org. Biomol. Chem., 2020,18, 4739-4743
DOI:
10.1039/D0OB01002B,
Communication
Open Access Learn more..A highly efficient disulfide rebridging strategy for the modification of monoclonal antibodies with substituted divinyltriazine linkers is reported. The reaction proceeds efficiently under mild conditions with near stoichiometric quantities of linker. This method of conjugation yields serum stable antibody conjugates with a controlled payload loading of 4.
