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Abstract | Cited by

A convenient two-step method is reported for the ligation of alkoxyamine- or hydrazine-bearing cargo to proline N-termini. Using this approach, bifunctional proline N-terminal bioconjugates are constructed and proline N-terminal proteins are immobilized.

Graphical abstract: Secondary modification of oxidatively-modified proline N-termini for the construction of complex bioconjugates

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