Deyao Zhao, Ge Yang, Qing Liu, Wenjing Liu, Yuhua Weng, Yi Zhao, Feng Qu, Lele Li and Yuanyu Huang
Nanoscale, 2020,12, 10939-10943
DOI:
10.1039/D0NR00301H,
Communication
A photo-triggerable aptamer nanoswitch was proposed for spatiotemporal regulation of siRNA delivery. Recognition between AS1411 and nucleolin was effectively blocked by a photo-labile complementary oligonucleotide, which could be reactivated with photo-irradiation, resulting in efficient tumor-targeted siRNA internalization and gene silencing in vitro and in vivo.
