Issue 16, 2019

Synthesis of aminoboronic acid derivatives: an update on recent advances

Abstract

Both α- and β-aminoboronic acids and their derivatives are particularly useful as synthetic precursors, biochemical probes and drugs, although the development of novel compounds has long been hindered by the lack of synthetic options. We highlight the developments in this field, starting from the landmark Matteson homologation methodology, and moving to some elegant and convenient methods reported mainly over the last 4 years. Here, these novel and often very general methods are described and compared with each other, with their respective benefits and potential drawbacks defined. We focus on their stereoselectivity and determine whether the methods are substrate or catalyst controlled, or yield racemic mixtures.

Graphical abstract: Synthesis of aminoboronic acid derivatives: an update on recent advances

Article information

Article type
Highlight
Submitted
11 Cam 2019
Accepted
18 Wax 2019
First published
19 Wax 2019

Org. Chem. Front., 2019,6, 2991-2998

Synthesis of aminoboronic acid derivatives: an update on recent advances

A. Šterman, I. Sosič, S. Gobec and Z. Časar, Org. Chem. Front., 2019, 6, 2991 DOI: 10.1039/C9QO00626E

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