Issue 10, 2017

Silver-mediated fluorination of alkyl iodides with TMSCF3 as the fluorinating agent

Abstract

The first example of a silver-mediated fluorination of alkyl iodides with the Ruppert–Prakash reagent (TMSCF3) as a fluorinating agent has been reported. This reaction is compatible with a variety of functional groups and proceeds under mild reaction conditions. Moreover, we demonstrate that the large surface area of CaF2 dramatically increased the reaction yield.

Graphical abstract: Silver-mediated fluorination of alkyl iodides with TMSCF3 as the fluorinating agent

Supplementary files

Article information

Article type
Research Article
Submitted
08 Wax 2017
Accepted
26 Wax 2017
First published
27 Wax 2017

Org. Chem. Front., 2017,4, 1958-1961

Silver-mediated fluorination of alkyl iodides with TMSCF3 as the fluorinating agent

L. Wang, X. Jiang and P. Tang, Org. Chem. Front., 2017, 4, 1958 DOI: 10.1039/C7QO00450H

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