Issue 10, 2017

Iridium-catalyzed direct asymmetric reductive amination of aromatic ketones

Abstract

The highly efficient direct catalytic reductive amination of aromatic ketones with diphenylmethanamine is described. Catalyzed by the iridium–monodentate phosphoramidite complex and assisted using additives, this concise and practical route provided chiral amines in high yields and with high enantioselectivity (ee values of up to 99%).

Graphical abstract: Iridium-catalyzed direct asymmetric reductive amination of aromatic ketones

Supplementary files

Article information

Article type
Research Article
Submitted
21 Cam 2017
Accepted
27 Wax 2017
First published
28 Wax 2017

Org. Chem. Front., 2017,4, 1976-1980

Iridium-catalyzed direct asymmetric reductive amination of aromatic ketones

H. Huang, Z. Wu, G. Gao, L. Zhou and M. Chang, Org. Chem. Front., 2017, 4, 1976 DOI: 10.1039/C7QO00400A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements