Issue 17, 2015
From the journal:

RSC Advances

Colorimetric sensors with different reactivity for the quantitative determination of cysteine, homocysteine and glutathione in a mixture†

Li-Ya Niu,‡a   Ming-Yan Jia,‡b   Peng-Zhong Chen,a   Yu-Zhe Chen,a   Yuan Zhang,c   Li-Zhu Wu,a   Chun-Feng Duan,b   Chen-Ho Tung,ad   Ya-Feng Guan,b   Liang Feng*b  and  Qing-Zheng Yang*ac  

* Corresponding authors

a Key Lab of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, P. R. China.
E-mail: qzyang@mail.ipc.ac.cn

b Key Lab of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, Liaoning 116023, P. R. China.
E-mail: fengl@dicp.ac.cn

c College of Chemistry, Beijing Normal University, Beijing 100875, P. R. China

d College of Chemistry, Shandong Normal University, Jinan 250014, P. R. China

Abstract

We report a facile method for the quantitative detection of cysteine (Cys), homocysteine (Hcy) and glutathione (GSH) in a mixture. BODIPY-based sensors 1 and 2 are synthesized, and the diverse reactivities of 1 and 2 in the presence of a mixture of biothiols lead to distinct absorption spectra at a specified period of time. With a spectral analysis, we are capable of distinguishing three biothiols and achieving the quantitative determination of Cys, Hcy and GSH in a mixture.

Graphical abstract: Colorimetric sensors with different reactivity for the quantitative determination of cysteine, homocysteine and glutathione in a mixture

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Article information

DOI
https://doi.org/10.1039/C4RA16601A
Article type
Communication
Submitted
18 Mud 2014
Accepted
16 Ama 2015
First published
16 Ama 2015

RSC Adv., 2015,5, 13042-13045

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Colorimetric sensors with different reactivity for the quantitative determination of cysteine, homocysteine and glutathione in a mixture

L. Niu, M. Jia, P. Chen, Y. Chen, Y. Zhang, L. Wu, C. Duan, C. Tung, Y. Guan, L. Feng and Q. Yang, RSC Adv., 2015, 5, 13042 DOI: 10.1039/C4RA16601A

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