Yang Yang, Shunxi Dong, Xiaohua Liu, Lili Lin and Xiaoming Feng
Chem. Commun., 2012,48, 5040-5042
DOI:
10.1039/C2CC31470C,
Communication
The asymmetric direct vinylogous Michael reaction of α,β-unsaturated γ-butyrolactams with alkylidene malonates has been developed. Various 5-substituted 3-pyrrolidin-2-ones were obtained in high yields (up to 93%) with excellent stereoselectivities (up to 94% ee, 95 : 5 dr), using a novel bifunctional C1-symmetric guanidine organocatalyst embodied a secondary amine subunit.
