Rouven Stulz, Michael Lerche, Olivia Luige, Agnes Taylor, Stefan Geschwindner and Alice Ghidini
RSC Chem. Biol., 2023,4, 1123-1130
Abstract
Benefits of early implementation of HT, inexpensive and enhanced biophysical screenings to investigate the affinity of ASOs for their target RNA using several biophysical techniques such as DSF, ITC, SPR, CD and SAXS.
Suxiang Chen, Bal Hari Poudel and Rakesh N. Veedu
Chem. Commun., 2025,61, 17001-17004
Abstract
2′-OMe ASOs with a stereo-random PO–PS backbone were systematically explored regarding their design, RNA binding affinity, nuclease resistance, and exon skipping efficacy.
Takayuki Kanagawa, Aya Koyoma, Yoshiaki Masaki and Kohji Seio
Org. Biomol. Chem., 2023,21, 5214-5224
Abstract
Modifications of the guanine 2-amino group have the potential to suppress hybridization-dependent off-target effects and improve ASO selectivity.
Disha Kashyap, Thomas A. Milne and Michael J. Booth
Chem. Sci., 2025,16, 13096-13105
Abstract
Lysosomal-trafficking antisense oligonucleotides (LyTONs) allow for the lysosomal degradation of target mRNA-enabling potent gene silencing in the cytoplasm, via an RNase H-independent mechanism.
Mathijs J. Pals, Alexander Lindberg and Willem A. Velema
Chem. Soc. Rev., 2024,53, 11303-11320
Abstract
Antibacterial resistance is a severe threat to modern medicine and human health. Antisense technology offers an attractive modality for future antibiotics.