Chemodivergent synthesis of halogenated 1-pyrrolines, 3-azabicyclo[3.1.0]hex-2-enes and α,α-dibromo imines from N-allyl enamines via halide-controlled annulation.
Halogenic disinfectants have been shown to produce toxic and carcinogenic disinfection by-products in the water disinfection process.
A controllable spirocyclization of unsaturated barbiturates with enamines to selectively synthesize spirobarbiturates has been developed under ball-milling conditions.
Bromoaryl compounds have attracted great attention in organic chemistry, especially for the synthesis of pharmaceutical intermediates.
We report herein a visible-light-driven bromination/chlorination of 3° C(sp3)–H bonds without using any catalyst or solvent. This method features high site selectivity, scalability and excellent functional group tolerance, even in complex molecules.