Highly functionalized 3a,7a-dihydroxy hexahydro-4H-indol-4-ones were efficiently synthesized via a Ru(III)-catalyzed alkenyl C(sp2)–H bond functionalization/[3 + 2] annulation reaction between readily available enaminones and iodonium ylides.
A simple methodology for the synthesis of bicyclic 6,7-dihydrofuro[3,4-c]pyridines is reported. The skeletal diversity of the synthesized heterobicyclic frame may present new nitrogen- and oxygen-based hybrid systems for medicinal chemistry.
Research on the fluoro-functionalization of enaminones is summarized, presenting for the first time the advances in the synthesis of diverse fluorine-elaborated organic molecules by the various transformations of enaminones.
A simple, exogenous-base-free, and NBS-mediated C-selenocyanation/cyclization reaction of enaminones and enamino esters with KSeCN under mild conditions has been developed, providing a facile synthetic route to 2-aminoselenazole products.
The Rh-catalyzed C–H activation of N-pyridinyl enaminones and cascade cyclization with diazo compounds are reported to construct 2-pyrones and pyrido-quinazolinones by designing the directing group strategy.