Benzofuran moiety is the main component of many biologically active natural and synthetic heterocycles.
The gram-scale synthesis of benzofuranyl acetic acid via a Willgerodt–Kindler rearrangement is presented. Additionally, the antifungal activity against Fusarium oxysporum was tested for ten different benzofuranyl acetic acid amides.
The overexpression of VEGFR-2 and carbonic anhydrase IX (hCA IX), two proven therapeutic targets in aggressive malignancies, is closely associated with hypoxia-driven tumor growth.
Design and synthesis of novel benzofuran–pyrazole-based analogues conjugated with substituted aromatic and heterocyclic ring systems. 3d exhibited multi-kinase suppression activity against B-Raf (V600E), c-Met, Pim-1, EGFR (WT), and VEGFR-2.
A new series of proximicin analogues containing a benzofuran moiety as the replacement of the di-furan scaffold of the parent compound were synthesised and evaluated for their anti-proliferative activities against human glioblastoma cells U-87 MG.