Developments in the synthesis of indolizines during the last decade are reviewed, with special emphasis given to strategies relying on pyrrole derivatives and on π-expanded systems.
This review summarizes recent advances in electrochemical and photocatalytic C–H functionalization of indolizines, with an emphasis on the construction of C–C and C–X (X = S, Se, N, Cl, Br, etc.) bonds.
A sustainable electrochemical approach for site-selective C–H mono and bis-chalcogenation (sulfenylation or selenylation) of indolizine frameworks is described.
Tricyclic indolizines can be obtained in water in one step by a Morita–Baylis–Hillman/aza-Michael cyclization/dehydration cascade.
By using TEMPO and TBPB as oxidants under ball milling conditions, the synthesis of electron-rich indolizine derivatives via 1-alkenylation and 1,3-alkenylation has been established.