This minireview highlights recent advances in radical cyclization/addition of ynones. The content is organized according to product structure, providing a clearer overview and emphasizing the application value of ynones in radical chemistry.
Current study reflects a regioselective and efficient synthesis of less studied 2,4,5-trisubstituted pyrimidines via geminal ditosyloxy ketones. The methodology reduces the number of synthetic steps and also avoids the use of hazardous reagents.
Pyrazolone derived Ru(III) complexes were synthesized and applied as catalysts in the C–H activation reaction of α,β-unsaturated carbonyl compounds. In addition to Heck type coupling, ethanol mediated ethoxylation was also witnessed.
This study focused on design and synthesis of novel pyrazole-pyrrolinone and pyridazinone derivatives and evaluation of their antimicrobial, antibiofilm, and mechanistic properties to identify promising lead compounds.
Euphorbia tirucalli latex metabolites showed modest antibacterial activity against resistant Klebsiella pneumoniae; network pharmacology and molecular modeling supported putative target interactions.