This minireview highlights recent advances in radical cyclization/addition of ynones. The content is organized according to product structure, providing a clearer overview and emphasizing the application value of ynones in radical chemistry.
Current study reflects a regioselective and efficient synthesis of less studied 2,4,5-trisubstituted pyrimidines via geminal ditosyloxy ketones. The methodology reduces the number of synthetic steps and also avoids the use of hazardous reagents.
Pyrazolone derived Ru(III) complexes were synthesized and applied as catalysts in the C–H activation reaction of α,β-unsaturated carbonyl compounds. In addition to Heck type coupling, ethanol mediated ethoxylation was also witnessed.
A set of novel quinoline tethered cis-vinyl triamides derivatives has been designed, synthesized and screened for in vitro cytotoxicity against the MCF-7 breast adenocarcinoma cell line.
Antiviral screening of hydroxyquinoline-pyrazoles against SARS-CoV-2, MERS-CoV, and HCoV-229E revealed potent inhibition of SARS-CoV-2 at lower concentrations, highlighting their promise as therapeutic candidates against this highly pathogenic virus.