R. S. K. Vijayan, Matthew M. Hamilton, Dana E. Pfaffinger, Fernando G. Alvarez, Naphtali J. Reyna, Jennifer P. Bardenhagen, Hannah Shepard, Christian Rodriguez, Sunil Goodwani, Yaima Lightfoot, Klaus Maskos, Sven Johannsson, Georg Kempf, Quanyun Alan Xu, Lars Neumann, Yongying Jiang, Mary Geck Do, Philip Jones, Richard T. Lewis, William J. Ray and Jason B. Cross
RSC Med. Chem., 2025,16, 5341-5358
From themed collection:
Kinases
Abstract
Parallel virtual screening and structure-guided optimization enable discovery of novel allosteric RIPK1 inhibitors.
Ji-xiang Liu, Ri-song Na, Lian-juan Yang, Xu-ri Huang and Xi Zhao
Phys. Chem. Chem. Phys., 2023,25, 31418-31430
Abstract
Six small molecules from virtual screening hits may treat neurodegenerative diseases and SARS-CoV-2 by inhibiting RIPK1.
Zechen Jin, Yang Dai, Yinchun Ji, Xia Peng, Wenhu Duan, Jing Ai and Hefeng Zhang
RSC Med. Chem., 2024,15, 2514-2526
Abstract
This study reported a series of 6,7-dihydro-5H-pyrrolo[1,2-b][1,2,4]triazole derivatives with potent RIPK1 inhibitory activity and anti-necroptotic activity in both human and mouse cellular assays.
Apoorva J. Pradhan and G. Ekin Atilla-Gokcumen
Mol. Omics, 2023,19, 205-217
Abstract
Necroptosis is a type of programmed cell death associated with an inflammatory phenotype. Pradhan et al. reviews recent -omics-based studies that help better understand necroptotic signaling and inflammatory response associated with it.
Saman Hosseinkhani, Mojdeh Amandadi, Parisa Ghanavatian, Fateme Zarein, Farangis Ataei, Maryam Nikkhah and Peter Vandenabeele
Chem. Soc. Rev., 2024,53, 11557-11589
Abstract
This review provides a comprehensive overview of the use of bioluminescence assays in advancing our understanding and studying cell death modalities and autophagy.